Secondary insult reveals etiology of GATA2 enhancer mutation-associated blood disorder

The transcription factor GATA-2 is critical regulator of hematopoietic stem and progenitor cell (HSPC) development and function, and mutations in the enhancer region of GATA2 are linked to blood disorders. In this episode, Emery Bresnick and colleagues develop and characterize a mouse model that harbors a human disease-associated GATA2 enhancer mutation. In this model, hematopoietic development and function were normal unless the animals were exposed to a secondary stress that necessitated blood cell regeneration. The results of this study provide important insight into GATA-2-dependent pathogenesis.

Four faculty receive 2019 Hilldale Awards

SCRMC faculty member, Linda Schuler, was a member of the first class of professors hired to inaugurate the UW–Madison School of Veterinary Medicine in 1983. Her research defined the genetic details of the hormonal control of milk production in dairy cows. That work led Schuler to discover that the milk-stimulating hormone prolactin can induce breast cancer, distinguishing her as a researcher eager to pursue leads toward the next problem.

Video: Stem cells, lab to clinic

Forward Bio Institute director Bill Murphy and David Gamm, director of the McPherson Eye Research Institute, where stem cells are being turned into retinal cells to try to find cures for blinding disorders, explain how stem cell scientists are working with industry to put scientific breakthroughs on the path to helping patients.

Video: Stem cell summer camp

Every summer since 2007, students from some of the smallest high schools in Wisconsin have descended upon campus for the Morgridge Rural Summer Science Camp. The immersion program has allowed more than 500 high-academic achievers from across the state to spend a week learning from leaders in stem cell research. The students arrive passionate and motivated in science, but the hope is this deep dive into real research will seal the deal for a future scientific caree

Stem cells: Where are we going?

Together with the University of Wisconsin-Madison, we look back on 20 years of stem cell research and see where we’re going next. Catch up on what’s happened since James Thomson’s prescient prediction that stem cells “will change medicine, period.”