Orchard View Room in WID @ 12:00 pm - 1:00 pm
Title: Quantitative High-Throughput Screening of Human Neurodevelopment for Toxicology and Precision Medicine with RosetteArray™ Technology Abstract: Central nervous system (CNS) development begins with formation of the neural tube, the eventual source of all brain and spinal …
Orchard View Room in WID @ 12:00 pm - 1:00 pm
Title: Regulation and function of GAGA factor mitotic retention in the early Drosophila embryo Abstract: Development depends on the faithful maintenance of gene-expression programs as cells proliferate. During mitosis, chromatin condenses, transcription arrests, and most transcription …
Orchard View Room in WID @ 12:00 pm - 1:00 pm
Title: On the Factory Floor: Building Brains with Stem Cells Abstract: In this talk, I will take you on a guided tour of the manufacturing processes that build the brain, emphasizing the vital role of …
Orchard View Room in WID @ 12:00 pm - 1:00 pm
Title: Investigating the Synaptic Landscape of Trisomy 21 using human iPSCs Abstract: Down syndrome (DS) or trisomy 21 (T21) is the most common genetic cause of intellectual disability. Deficits in synaptic formation, function, and maintenance have …
Orchard View Room in WID @ 12:00 pm - 1:00 pm
Title: Decoding Cardiotoxicity with Human iPSCs and CRISPR Screens Abstract: Dr. Chun Liu is an Assistant Professor in the Department of Physiology at the Medical College of Wisconsin and Director of the CVRC iPSC Core. …
Orchard View Room in WID @ 12:00 pm - 1:00 pm
Title: Nuclei have Heart: A hERG1 Channel Subdomain Targets the Nucleus Abstract: hERG1NP, encoded by KCNH2, is a polypeptide expressed in the nuclei of developing cardiomyocytes. From the nucleus, hERG1NP activity reduces hERG1 current from …
DeLuca Forum in the Discovery Building @ 12:00 pm - 1:00 pm
Title: KMT2D acts through both enzyme-dependent and -independent mechanisms to regulate cell fate changes during muscle regeneration Abstract: Muscle regeneration is a multifaceted process reliant on the rapid response of muscle stem cells (MuSCs) to …
Orchard View Room in WID @ 12:00 pm - 1:00 pm
Title: Isoform-level transcriptional program of smooth muscle cells in coronary artery disease Abstract: Coronary artery disease (CAD) remains a leading cause of death worldwide, and is characterized by the buildup of plaques in the coronary …
Orchard View Room in WID @ 12:00 pm - 1:00 pm
Title: Fragile X Autosomal Homolog 1 (FXR1) is Required for the Development of Human Dorsal Forebrain Excitatory Neurons Abstract: Fragile X autosomal homolog 1 (FXR1) is a brain-enriched RNA-binding protein essential for neurodevelopment, as its loss …
Orchard View Room in WID @ 12:00 pm - 1:00 pm
Title: In vivo characterization of adult hippocampal neural stem cell behavior Abstract: Adult neural stem cells (NSC) are primarily quiescent, in reversible G0 of the cell cycle, and lose their ability to exit quiescence with aging …