Micro-molded ‘ice cube tray’ scaffold is next step in returning sight to injured retinas

Tens of millions of people worldwide are affected by diseases like macular degeneration or have had accidents that permanently damage the light-sensitive photoreceptors within their retinas that enable vision. The human body is not capable of regenerating those photoreceptors, but new advances by medical researchers and engineers at the University of Wisconsin–Madison may provide hope …

Metabolic switch may regenerate heart muscle following heart attack

Research from the University of Wisconsin–Madison finds that a new therapeutic approach for heart failure could help restore cardiac function by regenerating heart muscle. In a study recently published in the journal Circulation, the UW team describes its success in improving, in a mouse model, the function of heart muscle by temporarily blocking a key …

Individualized brain cell grafts reverse Parkinson’s symptoms in monkeys

Grafting neurons grown from monkeys’ own cells into their brains relieved the debilitating movement and depression symptoms associated with Parkinson’s disease, researchers at the University of Wisconsin–Madison reported today. In a study published in the journal Nature Medicine the UW team describes its success with neurons made from cells from the monkeys’ own bodies after …

UW vision researchers partner with U.S. Department of Defense to develop stem cell therapy for combat-related eye injuries

The project, led by David Gamm, MD, PhD, director of the McPherson Eye Research Institute and professor of ophthalmology and visual sciences at the UW School of Medicine and Public Health, will develop a transplantable patch to restore vision to members of the armed forces who have been injured by blasts or lasers. December 11, …

New Visualization Method Gets to the Heart of Parkinson’s Disease

This week, the NIH Office of Research Infrastructure Programs highlights Dr. Marina Emborg, her WNPRC lab team and their UW–Madison colleagues’ advances in detecting heart disease in Parkinson’s and evaluating new therapies that specifically target nerve disease within the human heart. December 2020

Celebrating 25 years of embryonic stem cell research at UW–Madison

It’s been 25 years since University of Wisconsin–Madison scientist James Thomson became the first in the world to successfully isolate and culture primate embryonic stem cells. He accomplished this breakthrough first with nonhuman primates at the Wisconsin National Primate Research Center in 1995, using rhesus monkey cells, then in 1996 with marmoset cells. Thomson then …

Study points way to possible new treatment for ligament injuries

“EEMs and exosomes each have attractive characteristics as therapeutics,” Dr. Hematti, UW–Madison’s Department of Medicine, noted.” As a cell therapy, EEMs will not proliferate or differentiate to undesirable cell types, which remains a concern for many stem cell therapies. Moreover, EEMs could be generated from a patient’s own monocytes using off-the-shelf exosomes, resulting in a …

Stem cells can repair Parkinson’s-damaged circuits in mouse brains

University of Wisconsin–Madison researchers, led by UW–Madison neuroscientist Su-Chun Zhang, demonstrated a proof-of-concept stem cell treatment in a mouse model of Parkinson’s disease. They found that neurons derived from stem cells can integrate well into the correct regions of the brain, connect with native neurons and restore motor functions. The findings have been published in the …

Dr. Hematti receives bonus acknowledgement from Be The Match

Be the match extended their sincere gratitude for Dr. Hematti’s commitment to patients and donors. Despite the challenges that have been faced over the past several months, this commitment hasn’t faded and, in fact, has shone a light on the dedication and diligence that Dr. Hematti’s and his team have put forth to the common …

Simpler COVID-19 test could provide results in hours from saliva

Scientists from UW–Madison’s AIDS Vaccine Research Laboratory have tuned a relatively simple genetic testing process to find evidence of the novel coronavirus in saliva. David Beebe, a UW–Madison pathology professor and Salus,  joined the group to design and produce an extraction process that would work outside lab settings and make the RT-LAMP test much more …