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SCRMC investigators will advance the science of blood stem cell biology through five novel projects

Five innovative projects studying blood stem cells are currently underway at the University of Wisconsin–Madison. Led by Stem Cell and Regenerative Medicine Center (SCRMC) investigators and supported by a gift from the Wisconsin Alumni Research Foundation (WARF), these projects will investigate a wide variety of blood-based processes, from the role of inflammation in blood cell …

The 2024 Annual Report is now available!

We invite you to explore the 2024 SCRMC Annual Report which includes research highlights, event updates, and so much more. We would also like to thank our amazing members as well as all who have supported the Center this year. Without your contributions, this important work would not be possible- thank you! To request a …

Congratulations to the Summer Undergraduate Research Fellowship (SURF) Award Winners!

This story has been archived. For assistance, please contact SCRMC@medicine.wisc.edu The Stem Cell and Regenerative Medicine Center labs will welcome five new members this summer, as a part of the Summer Undergraduate Research Fellowship (SURF), which supports motivated University of Wisconsin–Madison undergraduate students as they pursue research in stem cell science and regenerative medicine. These talented undergraduate …

Donor-supported study leads the way for new regenerative therapies by revealing the mechanism controlling the efficiency of iPSC generation

By Bekah McBride A new approach is paving the way for improved stem cell therapies and regenerative applications using cells from pigs. Led by Wan-Ju Li, a SCRMC researcher and associate professor in the Department of Orthopedics and Rehabilitation  and the Department of Biomedical Engineering, this new study published in Scientific Reports offers a viable …

New study identifies protein essential to form stem cell-derived human heart cells

By Bekah McBride Lab-grown human heart cells provide a powerful tool to understand and potentially treat heart disease. However, the methods to produce human heart cells from pluripotent stem cells are not optimal. Fortunately, a new study out of the University of Wisconsin–Madison Stem Cell & Regenerative Medicine Center, is providing key insight that will …

SCRMC researchers uncover how stem cell-derived photoreceptors reach their targets

A new study investigating the growth of photoreceptors may have implications for the treatment of retinal diseases that cause blindness. The study, published in  Cell Reports, was led by Stem Cell and Regenerative Medicine (SCRMC) researcher Timothy Gomez, professor of neuroscience, Sarah Rempel, a postdoctoral researcher in the Gomez lab, and SCRMC researcher David Gamm, professor …

Hundreds attend 16th Wisconsin Stem Cell Symposium focusing on stem cell competition

On April 20, 2022, more than 260 students and researchers gathered for the 16th Wisconsin Stem Cell Symposium in Madison, Wis. Co-hosted by the Stem Cell and Regenerative Medicine Center (SCRMC) and the BioPharmaceutical Technology Center Institute (BTC Institute), this annual event highlights the latest advances in stem cell science and technology. This year, the symposium focused on stem cell competition, which has important implications for healthy aging and disease states. Throughout the day, virtual and in-person attendees heard from seven of the world’s leading researchers studying stem cell competition. Additionally, attendees participated in a rapid-fire poster session that included twelve presentations by graduate and post-doctoral researchers. The conversation continued during the lunch and networking session, with the rapid-fire presenters as well as eighteen other researchers sharing their posters throughout the event hall. The SCRMC and the BTC Institute thank all who attended as well as the sponsors who helped to make this event a success.

Team of SCRMC researchers help to improve quality control for biomanufacturing stem cells

A team of University of Wisconsin-Madison researchers, including members of the Stem Cell and Regenerative Medicine Center (SCRMC), have developed an innovative methodology that can ultimately be used to advance cutting-edge personalized therapies and disease models. The study, published in the journal GEN Biotechnology, outlines the new methodology which includes a real-time method for tracking the reprogramming of somatic cells to induce pluripotent stem cells (iPSCs) using micropatterning, label-free imaging, and machine learning. This novel study was led by Kaivalya Molugu, a recent PhD graduate in biophysics who worked in SCRMC faculty member and College of Engineering Associate Professor, Krishanu Saha’s lab where Molugu was funded through a Stem Cell and Regenerative Graduate fellowship. The study was a collaborative project with SCRMC faculty member and Professor of Biological Engineering, Melissa Skala’s lab.

New tool for assessing heart muscle cells helps unlock their potential

Dr. Wendy Crone and her team have created a new technique for coaxing immature cardiomyocytes to become mature cells with highly organized internal structures. June 25, 2020

Newly identified cellular trash removal program helps create new neurons

Assistant Professor of Neuroscience Darcie Moore led work with graduate student Christopher Morrow to discover how a cellular filament helps neural stem cells clear damaged and clumped proteins, an important step in eventually producing new neurons. Feb. 27, 2020