Nathan Welham, PHD, CCC-SLP

Position title: Professor, Otolaryngology / Surgery


Phone: 608-263-4320

Organ System/Disease Focus:
Vocal fold tissue repair/regeneration
Aligned Research Focus:
Prevention and treatment of fibrosis. Tissue engineering. Systems biology, proteomics, and matrisomics.
Nathan Welham headshot


More information:
Research Description:

Our work focuses on vocal fold mucosal biology in normal and pathologic states, retinoid biology, and mucosal engineering.

Selected References:
  • Rolfs Z, Frey BL, Shi X, Kawai Y, Smith LM, Welham NV. An atlas of protein turnover rates in mouse tissues. Nat Commun. 2021 Nov 26;12(1):6778. doi: 10.1038/s41467-021-26842-3. PMID: 34836951; PMCID: PMC8626426.
  • Ling C, Li Q, Brown ME, Kishimoto Y, Toya Y, Devine EE, Choi KO, Nishimoto K, Norman IG, Tsegyal T, Jiang JJ, Burlingham WJ, Gunasekaran S, Smith LM, Frey BL, Welham NV. Bioengineered vocal fold mucosa for voice restoration.  Sci Transl Med. 2015 Nov 18;7(314):314ra187. doi: 10.1126/scitranslmed.aab4014. PMID: 26582902
  • Li Q, Uygun BE, Geerts S, Ozer S, Scalf M, Gilpin SE, Ott HC, Yarmush ML, Smith LM, Welham NV, Frey BL. Proteomic analysis of naturally-sourced biological scaffolds.  Biomaterials. 2016 Jan;75:37-46. doi: 10.1016/j.biomaterials.2015.10.011. Epub 2015 Oct 8. PMID: 26476196
  • Chang Z, Kishimoto Y, Hasan A, Welham NV. TGF-β3 modulates the inflammatory environment and reduces scar formation following vocal fold mucosal injury in rats. Dis Model Mech. 2014 Jan;7(1):83-91. doi: 10.1242/dmm.013326. Epub 2013 Oct 2. PMID: 24092879
  • Li Q, Chang Z, Oliveira G, Xiong M, Smith LM, Frey BL, Welham NV. Protein turnover during in vitro tissue engineering. Biomaterials. 2016 Mar;81:104-13. doi: 10.1016/j.biomaterials.2015.12.004. Epub 2015 Dec 14.
  • Ling C,, Nishimoto K, Rolfs Z, Smith LM Frey BL, Welham NV. Differentiated fibrocytes assume a functional mesenchymal phenotype with regenerative potential. Science Advances [08 May 2019, 5(5):eaav7384], (PMID:31086819 PMCID:PMC6506241).