Nader Sheibani, PHD

Position title: Professor, Ophthalmology and Visual Sciences


Website: Nader Sheibani, PHD's website

Phone: 608-263-3345

Organ System/Disease Focus:
Retina/ Diabetic Retinopathy and Age-Related Macular Degeneration
Aligned Research Focus:
Vascular Cell Biology
Nader Sheibani headshot


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Research Description:

My major research interest is how angiogenesis is regulated with a focus on the role of endogenous inhibitors of angiogenesis. We have recently become interested in potential contribution of endothelial progenitor cells in angiogenesis and what determines their appropriate differentiation to vascular cells during this process. We are also interested in the function of perivascular mesenchymal stems cells and innate immune regulatory cells in angiogenesis and their dysfunction during diabetes and aging.

Selected References:
  • Fingolimod (FTY720), a Sphinogosine-1-Phosphate Receptor Agonist, Mitigates Choroidal Endothelial Proangiogenic Properties and Choroidal Neovascularization. Sorenson CM, Farnoodian M, Wang S, Song YS, Darjatmoko SR, Polans AS, Sheibani N. Cells. 2022 Mar 11;11(6):969. doi: 10.3390/cells11060969. PMID: 35326420
  • Bim Expression Promotes the Clearance of Mononuclear Phagocytes during Choroidal Neovascularization, Mitigating Scar Formation in Mice. Wang S, Zaitoun IS, Darjatmoko SR, Sheibani N, Sorenson CM. Life (Basel). 2022 Jan 29;12(2):208. doi: 10.3390/life12020208. PMID: 35207495
  • Caffeine Inhibits Choroidal Neovascularization Through Mitigation of Inflammatory and Angiogenesis Activities. Sorenson CM, Song YS, Zaitoun IS, Wang S, Hanna BA, Darjatmoko SR, Gurel Z, Fisk DL, McDowell CM, McAdams RM, Sheibani N. Front Cell Dev Biol. 2021 Oct 14;9:737426. doi: 10.3389/fcell.2021.737426. eCollection 2021. PMID: 34722519
  • Hypoxic-Ischemic Encephalopathy: Impact on Retinal Neurovascular Integrity and Function. Zaitoun IS, Sheibani N.J Ophthalmic Vis Res. 2021 Jul 29;16(3):317-319. doi: 10.18502/jovr.v16i3.9427. eCollection 2021 Jul-Sep. PMID: 34394859
  • Targeted Thrombospondin-1 Expression in Ocular Vascular Development and Neovascularization. Sorenson CM, Wang S, Darjatmoko SR, Gurel Z, Liu B, Sheibani N. Front Cell Dev Biol. 2021 Apr 21;9:671989. doi: 10.3389/fcell.2021.671989. eCollection 2021. PMID: 33968943
  • Hypoxic-ischemic injury causes functional and structural neurovascular degeneration in the juvenile mouse retina. Zaitoun IS, Shahi PK, Suscha A, Chan K, McLellan GJ, Pattnaik BR, Sorenson CM, Sheibani N. Sci Rep. 2021 Jun 16;11(1):12670. doi: 10.1038/s41598-021-90447-5. PMID: 34135369