Nader Sheibani, PHD

Position title: Professor and RRF/Alice R. McPherson Chair, Dept. of Ophthalmology and Visual Sciences

Email: nsheibanikar@wisc.edu

Website: Nader Sheibani, PHD's website

Phone: 608-263-3345

Organ System/Disease Focus:: Retina/ Diabetic Retinopathy and Age-Related Macular Degeneration
Aligned Research Focus:: Vascular Cell Biology

Pubmed

News Releases:

Researchers aim to broaden understanding of how toxins affect the body, 25 March 2015

More information:

Sheibani Laboratory Home Page

Research Description:

My major research interest is how angiogenesis is regulated with a focus on the role of endogenous inhibitors of angiogenesis. We have recently become interested in potential contribution of endothelial progenitor cells in angiogenesis and what determines their appropriate differentiation to vascular cells during this process. We are also interested in the function of perivascular mesenchymal stems cells and innate immune regulatory cells in angiogenesis and their dysfunction during diabetes and aging.

Selected References:

1.	Suboptimal Responses to Anti-VEGF in Retinal Neurovascular Diseases: Linking Aging and Alternative Angioinflammatory Pathways. Piroozmand S, Latifi-Navid H, Soheili ZS, Hosseinkhani S, Samiei S, Barzegar Behrooz A, Ahmadieh H, Leonardi A, Ghavami S, Sheibani N. Invest Ophthalmol Vis Sci. 2026 May 1;67(5):4. doi: 10.1167/iovs.67.5.4. PMID: 42080790 Free PMC article. Review.
2.	Diabetes associated pericyte metabolic signatures and pathogenesis of diabetic retinopathy. Carrillo C, Belecky-Adams TL, Sheibani N. Front Endocrinol (Lausanne). 2026 Mar 6;17:1771836. doi: 10.3389/fendo.2026.1771836. eCollection 2026. PMID: 41869040 Free PMC article. Review.
3.	Caffeine Mitigates Adenosine-Mediated Angiogenic Properties of Choroidal Endothelial Cells Through Antagonism of A₁ Adenosine Receptor and PI3K-AKT Axis. Park S, Song YS, Feng X, Sorenson CM, Sheibani N. Cells. 2026 Jan 5;15(1):87. doi: 10.3390/cells15010087. PMID: 41511370 Free PMC article.
4.	Pericyte Expression of VEGF-A Minimally Impacts Ocular Vascular Development and Neovascularization. Song YS, Wang S, Inampudi S, Risa H, Sorenson CM, Sheibani N. Cells. 2025 Sep 21;14(18):1473. doi: 10.3390/cells14181473. PMID: 41002438 Free PMC article.
5.	Intracellular Signaling Pathways and Their Potential Targeting for Treatment of Ocular Posterior Segment Fibrosis. Motevasseli T, Seraj A, Daftarian N, Kanav MR, Ahmadieh H, Sheibani N. J Ophthalmic Vis Res. 2025 May 21;20:10.18502/jovr.v20.16966. doi: 10.18502/jovr.v20.16966. eCollection 2025. PMID: 40689128 Free PMC article. Review.
6.	Pericytes and Diabetic Microangiopathies: Tissue Resident Mesenchymal Stem Cells with High Plasticity and Regenerative Capacity. Shirbaghaee Z, Sorenson CM, Sheibani N. Int J Mol Sci. 2025 Jun 1;26(11):5333. doi: 10.3390/ijms26115333. PMID: 40508141 Free PMC article. Review.
7.	Isolation and Characterization of Mouse Choroidal Melanocytes and Their Proinflammatory Characteristics. Song YS, Park S, Fisk D, Sorenson CM, Sheibani N. Cells. 2025 Apr 28;14(9):646. doi: 10.3390/cells14090646. PMID: 40358170 Free PMC article.