Eric G. Schmuck, PHD

Position title: Senior Scientist, Cardiovascular Medicine

Phone: 608-263-9449

Organ System/Disease Focus:: Cardiovascular disease
Aligned Research Focus:: Cardio-regenerative medicine, Biomaterials, Stem Cell Tracking, Translational research models, Cardiac fibroblast biology

Research Description:

Dr. Schmuck is a senior scientist and Director of Translational Research for the Dr. Amish Raval Laboratory. His research centers around novel therapies for cardiac regeneration. Specifically, a novel biomaterials generated in their lab that have been shown to improve cardiac function alone or in combination with therapeutic stem cells. This innovative material is a cell derived extracellular matrix that is self-adherent to the heart, bioactive and bio-absorbable. In addition, our laboratory focuses on cardiac fibroblasts biology, translational animal models of cardiovascular disease and stem cell tracking.

Selected References:

Schmuck EG, Roy S, Dhillon A, Walker S, Spinali K, Colevas S, Zhou T, Chhabra G, Liu Y, Kader Sagar MA, Childs CJ, Kink JA, Eliceiri KW, Hematti P, Raval AN. Cultured cardiac fibroblasts and myofibroblasts express Sushi Containing Domain 2 and assemble a unique fibronectin rich matrix. Exp Cell Res. 2021 Feb 15;399(2):112489. doi: 10.1016/j.yexcr.2021.112489. Epub 2021 Jan 14. PubMed PMID: 33453237.
Roy S, Spinali K, Schmuck EG, Kink JA, Hematti P, Raval AN. Cardiac fibroblast derived matrix-educated macrophages express VEGF and IL-6, and recruit mesenchymal stromal cells. J Immunol Regen Med. 2020 Dec;10. doi: 10.1016/j.regen.2020.100033. Epub 2020 Oct 21. PubMed PMID: 33564732; PubMed Central PMCID: PMC7869854.
Schmuck EG, Hacker TA, Schreier DA, Chesler NC, Wang Z. Beneficial effects of mesenchymal stem cell delivery via a novel cardiac bioscaffold on right ventricles of pulmonary arterial hypertensive rats. Am J Physiol Heart Circ Physiol. 2019 May 1;316(5):H1005-H1013. doi: 10.1152/ajpheart.00091.2018. Epub 2019 Mar 1. PubMed PMID: 30822119; PubMed Central PMCID: PMC6580387.
Zhang J, Tao R, Campbell KF, Carvalho JL, Ruiz EC, Kim GC, Schmuck EG, Raval AN, da Rocha AM, Herron TJ, Jalife J, Thomson JA, Kamp TJ. Functional cardiac fibroblasts derived from human pluripotent stem cells via second heart field progenitors. Nat Commun. 2019 May 20;10(1):2238. doi: 10.1038/s41467-019-09831-5. PubMed PMID: 31110246; PubMed Central PMCID: PMC6527555.
Schmuck EG, Koch JM, Centanni JM, Hacker TA, Braun RK, Eldridge M, Hei DJ, Hematti P, Raval AN. Biodistribution and Clearance of Human Mesenchymal Stem Cells by Quantitative Three-Dimensional Cryo-Imaging After Intravenous Infusion in a Rat Lung Injury Model. Stem Cells Transl Med. 2016 Dec;5(12):1668-1675. doi: 10.5966/sctm.2015-0379. Epub 2016 Jul 26. PubMed PMID: 27460855; PubMed Central PMCID: PMC5189648.
Schmuck EG, Koch JM, Hacker TA, Hatt CR, Tomkowiak MT, Vigen KK, Hendren N, Leitzke C, Zhao YQ, Li Z, Centanni JM, Hei DJ, Schwahn D, Kim J, Hematti P, Raval AN. Intravenous Followed by X-ray Fused with MRI-Guided Transendocardial Mesenchymal Stem Cell Injection Improves Contractility Reserve in a Swine Model of Myocardial Infarction. J Cardiovasc Transl Res. 2015 Oct;8(7):438-48. doi: 10.1007/s12265-015-9654-0. Epub 2015 Sep 15. PubMed PMID: 26374144; PubMed Central PMCID: PMC5006679.
Schmuck EG, Mulligan JD, Ertel RL, Kouris NA, Ogle BM, Raval AN, Saupe KW. Cardiac fibroblast-derived 3D extracellular matrix seeded with mesenchymal stem cells as a novel device to transfer cells to the ischemic myocardium. Cardiovasc Eng Technol. 2014 Mar 1;5(1):119-131. doi: 10.1007/s13239-013-0167-1. PubMed PMID: 24683428; PubMed Central PMCID: PMC3964807.