William L. Murphy, PHD

Position title: Professor, Biomedical Engineering, Orthopedics & Rehabilitation

Email: wlmurphy@wisc.edu

Phone: 608-265-9978

Organ System/Disease Focus:
Orthopedic and cardiovascular
Aligned Research Focus:
Tissue engineering, controlled stem cell culture
William Murphy headshot


News Releases:
More information:
Research Description:

In the Bioinspired Materials Laboratory, we are interested in developing “smart” biomaterials that mimic the complex signaling environments of natural tissue development. We place particular emphasis on temporal and spatial control over growth factor activity, gene transfer, and mechanical stimulation.
The materials developed in our lab are then used to understand and control stem cell differentiation, ultimately geared towards directed regeneration of a variety of human tissues. Our group is highly interdisciplinary, with research areas ranging from novel materials design approaches to basic stem cell biology.

Selected References:
  • Aisenbrey, W.L. Murphy. Synthetic alternatives to Matrigel. Nature Reviews Materials, 2020; 5: 539-551.
  • S. Khalil, X.Yu, J.M. Umhoefer, G.M. Diarrad, T.A. Hacker, W.L. Murphy. Single dose mRNA therapy via biomaterial-mediated sequestration of overexpressed proteins. Science Advances, 2020; 6: eaba2422.
  • Kaushik, K. Gupta, V. Harms, E. Torr, J. Evans, H.J. Johnson, C. Soref, S. Acevedo-Acevedo, J. Antosiewicz-Bourget, D. Mamott, P. Uhl, B.P. Johnson, S.P. Palecek, D.J. Beebe, J.A. Thomson, W.T. Daly, W.L. Murphy. Engineered perineural vascular plexus for modeling developmental toxicity. Advanced Healthcare Materials, 2020;9:e2000825.
  • Aisenbrey, E. Torr, H. Johnson, C. Soref, W. Daly, W.L. Murphy. A protocol for rapid pericyte differentiation of human induced pluripotent stem cells. STAR Protocols, 2021; 2: 100261.
  • W. Xie, N.A. Zacharias, W.L. Murphy. Controlled aggregation enhances immunomodulatory potential of mesenchymal stromal cell aggregates. Stem Cells Translational Medicine, 2021; 10: 1184-1201.