Deane Mosher, MD
Position title: Professor, Medicine / Biomolecular Chemistry
Email: dfmosher@wisc.edu
Phone: 608-262-1576
- Organ System/Disease Focus:
- Lung, hematopoietic tissue
- Aligned Research Focus:
- Roles of extracellular matrix and cell adhesion
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Research Description:
We compare eosinophils and neutrophils, two terminally differentiated blood cells; describe the states of the highly condensed chromatin in these cells; learn how the cells remodel chromatin to direct changes in gene transcription needed to sustain themselves and function in inflamed tissues; and learn how chromatin in these terminally differentiated cells differs from that of the myeloid cells that are common precursors to the two cell types. We also study the structure and function of non-collagenous proteins of extracellular matrix in directing formation of bone and other tissues with an emphasis on fibronectin, vitronectin, periostin, and TGFβ-induced globulin.
Selected References:
- Johansson MW, Annis DS, Mosher DF. (2013) αMβ2 integrin-mediated adhesion and motility of interleukin 5-stimulated eosinophils on periostin. Am J Resp Cell Mol Biol:48:503-10.