Darcie L. Moore, PHD
Position title: Assistant Professor, Neuroscience
Email: darcie.moore@wisc.edu
Phone: 608-265-7836
- Organ System/Disease Focus:
- Brain, Aging
- Aligned Research Focus:
- Aligned Research Focus: Mammalian neural stem cell biology, aging
More information:
Research Description:
Stem cell compartments undergo dysfunction with age, ultimately contributing to greater organismal aging. Understanding how and why these stem cells age is a main focus of our lab. Young mammalian neural stem cells can segregate specific cargoes during mitosis between daughter cells resulting in an asymmetric inheritance of potential “aging factors,” with downstream functional consequences for each daughter. In neural stem cells from old animals, this segregation becomes more symmetric. We are investigating the mechanisms that create and maintain this segregation, and identifying what changes with age. Additionally, we are interested in discovering what cargoes are segregated and the cost of this segregation.
Selected References:
- C.S. Morrow, T.J. Porter, N. Xu, Z.P. Arndt, K. Ako-Asare, H.J. Heo, E.A.N. Thompson, D.L. Moore (2020). Vimentin coordinates protein turnover at the aggresome during neural stem cell quiescence exit. Cell Stem Cell, 26(4):558-568.e9. PMID: 32109376
- C.S. Morrow, D.L. Moore (2020). Vimentin’s side gig: Regulating cellular proteostasis in mammalian systems. Cytoskeleton, 77(11): 515-523. PMID: 33190414 (peer-reviewed)
- M.K. Imtiaz, B.N. Jaeger, S. Bottes, R.A.C. Machado, M. Vidmar, D.L. Moore*, S. Jessberger* (2021). Decline of Lamin B1 expression mediates an age-dependent drop of hippocampal stem cell activity. Cell Stem Cell, 28(5):967-977.e8. PMID: 33631115. *co-corresponding author
- C.S. Morrow, T.J. Porter, D.L. Moore (2021). Fluorescent tagging of endogenous proteins with CRISPR/Cas9 in primary mouse neural stem cells. STAR Protocols, 2(3):100744. PMID: 34430917