Darcie L. Moore, PHD

Pubmed

More information:

• Dr. Moore’s Neuroscience Department Home page

Research Description:

There is limited regenerative capacity in the adult mammalian central nervous system (CNS). My lab studies this loss of regeneration in two different contexts:

• Adult neurogenesis, where neural stem cells (NSCs) make newborn neurons in the adult brain
• CNS axon regeneration following an injury

Specifically, we determine how changes during development and aging influence these aspects of regeneration.

Selected References:

• K. Samimi, O. Pasachhe, E. Guzman, J. Riendeau, A.A. Gillette, D.L. Pham, K.J. Wiech, D.L. Moore, M.C. Skala (2024). Autofluorescence lifetime flow cytometry with time-correlated single photon counting. Cytometry A, 2024 Aug;105(8):607-620. PMID: 38943226.
• C.S. Morrow, A.A. Gillette, M.C. Skala, D.L. Moore (2024). Classification of neural stem cell activation state in vitro using autofluorescence. Journal of Visualized Experiments (JOVE), 2024 Apr 12:(206). PMID: 38682901
• C.S. Morrow, K. Tweed, S. Farhadova, A.J. Walsh, B.P. Lear, A. Roopra, R.D. Risgaard, P.C. Klosa, Z.P. Arndt, E.R. Peterson, M.M. Chi, A.G. Harris, M.C. Skala, D.L. Moore (2024). Autofluorescence is a biomarker of neural stem cell activation state. Cell Stem Cell, 31(4):570-581.e7. PMID: 38521057
• B. P. Lear, D.L. Moore (2023). Moving CNS axon growth and regeneration research into human model systems. Review. Front. Neurosci. 17:1198041. doi: 10.3389/fnins.2023.1198041.
• B.P. Lear*, E.A.N. Thompson*, K. Rodriguez, Z.P. Arndt, S. Khullar, P.C. Klosa, R.J. Lu, C.S. Morrow, R. Risgaard, E.R. Peterson, B.B. Teefy, A. Bhattacharyya, A.M.M. Sousa, D. Wang, B.A. Benayoun, D.L. Moore (2023). Age-maintained human neurons demonstrate a developmental loss of intrinsic neurite growth ability. bioRxiv 2023.05.23.541995; doi: https://doi.org/10.1101/2023.05.23.541995
• C.S. Morrow, Z.P. Arndt, P.C. Klosa, B. Peng, E.Y. Zewdie, B.A. Benayoun, D.L. Moore (2022). Adult fibroblasts use aggresomes only in distinct cell-states. Scientific Reports, 2022 Sep 2;12(1):15001. PMID: 36056070
• M.K. Imtiaz, B. Jaeger, S. Bottes, R. Machado, M. Vidmar, D.L. Moore*, S. Jessberger* (2021). Declining Lamin B1 expression mediates age-dependent decreases of hippocampal stem cell activity. Cell Stem Cell, 2021 May 6;28(5):967-977.e8. PMID: 33631115 *co-corresponding authors
• C.S. Morrow, T.J. Porter, N. Xu, Z.P. Arndt, K. Ako-Asare, H.J. Heo, E.A.N. Thompson, D.L. Moore (2020). Vimentin coordinates protein turnover at the aggresome during neural stem cell quiescence exit. Cell Stem Cell, 26(4):558-568.e9. PMID: 32109376