Mark D. Markel, DVM, PHD

Position title: Dean, School of Veterinary Medicine


Phone: 608-262-3573

Organ System/Disease Focus:
Musculoskeletal regeneration
Aligned Research Focus:
Tissue engineering of bone and cartilage
Mark Markel headshot


More information:

Dr. Markel is Dean of the School of Veterinary Medicine, UW-Madison; a Vilas Distinguished Achievement Professor; and Treasurer of the Association of American Veterinary Medical Colleges.

Research Description:

The Comparative Orthopaedic Research Laboratory which I co-direct is focused on the regeneration of both bone and cartilage. In bone, we have focused our efforts on the creation of bioengineered scaffolds which incorporate cytokines such as various bone morphogenetic proteins in order to enhance healing of critical sized bone defects. In cartilage, we have helped develop bioengineered constructs through the use of allogeneic, xenogeneic, and autogeneic chondrocytes and/or mesenchymal stem cells to create cartilage transplants for critical-sized cartilage defects.

Selected References:
  • Racette M, Al saleh H, Block WF, Waller KR 3rd, Bleedorn JA, McCabe RP, Vanderby R Jr, Markel MD, Brounts SH, Muir P: 3D FSE cube and VIPR-aTR 3.0 Tesla magnetic resonance imaging predicts canine cranial cruciate ligament structural properties. Vet J 2016 Mar;209:150-5. doi: 10.1016/j.tvjl.2015.10.055. Epub 2015 Nov 4.
  • Biedrzycki AH, Grant BG, Nemke B, Morello SL, Markel MD: In vitro biomechanical evaluation of four surgical techniques for fusion of equine centrodistal and tarsometatarsal joints. Am J Vet Res 2016 Oct;77(10): 1071-81. doi: 10.2460/ajvr.77.10.1071.

  • Rustom LE, Boudou T, Lou S, Pignot-Paintrand I, Nemke BW, Lu Y, Markel MD, Picart C, Wagoner Johnson AJ: Micropore-induced capillarity enhances bone distribution in vivo in biphasic calcium phosphate scaffolds. Acta Biomater 2016 Oct 15;44: 144-54. doi: 10.1016/j.actbio.2016.08.025. Epub 2016 Aug 17.

  •  Yu X, Biedrzycki AH, Khalil AS, Hess D, Umhoefer JM, Markel MD, Murphy WL: Nanostructured mineral coatings stabilize proteins for therapeutic delivery. Adv Mater 2017 Jul 4. doi:  10.1002/adma.291701255.

  • Bleedorn JA, Hornberger TA, Goodman CA, Hao Z, Sample SJ, Amene E, Markel MD, Behan M, Muir P.  Temporal mechanically-induced signaling events in bone and dorsal root ganglion neurons after in vivo bone loading.  PLoS One 2018 Feb 27;13(2):e0192760: 10.1371/journal.pone.0192760.