Mark D. Markel, DVM, PHD
Position title: Dean, School of Veterinary Medicine
- Organ System/Disease Focus:
- Musculoskeletal regeneration
- Aligned Research Focus:
- Tissue engineering of bone and cartilage
Dr. Markel is Dean of the School of Veterinary Medicine, UW-Madison; a Vilas Distinguished Achievement Professor; and Treasurer of the Association of American Veterinary Medical Colleges.
The Comparative Orthopaedic Research Laboratory which I co-direct is focused on the regeneration of both bone and cartilage. In bone, we have focused our efforts on the creation of bioengineered scaffolds which incorporate cytokines such as various bone morphogenetic proteins in order to enhance healing of critical sized bone defects. In cartilage, we have helped develop bioengineered constructs through the use of allogeneic, xenogeneic, and autogeneic chondrocytes and/or mesenchymal stem cells to create cartilage transplants for critical-sized cartilage defects.
- Racette M, Al saleh H, Block WF, Waller KR 3rd, Bleedorn JA, McCabe RP, Vanderby R Jr, Markel MD, Brounts SH, Muir P: 3D FSE cube and VIPR-aTR 3.0 Tesla magnetic resonance imaging predicts canine cranial cruciate ligament structural properties. Vet J 2016 Mar;209:150-5. doi: 10.1016/j.tvjl.2015.10.055. Epub 2015 Nov 4.
- Bleedorn JA, Hornberger TA, Goodman CA, Hao Z, Sample SJ, Amene E, Markel MD, Behan M, Muir P. Temporal mechanically-induced signaling events in bone and dorsal root ganglion neurons after in vivo bone loading. PLoS One 2018 Feb 27;13(2):e0192760: 10.1371/journal.pone.0192760.