Anna Huttenlocher, MD, PhD

Position title: Professor of Pediatrics and Medical Microbiology and Immunology

Email: huttenlocher@wisc.edu

Phone: 608-265-4669

Organ Focus/Disease Focus
Wound healing Innate immunity and iPS derived neutrophils
Aligned Research Focus
Engineering of human iPS derived innate immune cells

Website: https://huttenlocher.labs.wisc.edu/

Research Description

We seek to understand how cell migration is regulated and how defects in cell migration contribute to human disease. Our recent work has centered on understanding how leukocytes are recruited to sites of tissue damage and resolution of inflammation by neutrophil reverse migration. Toward these goals her laboratory has developed tools to image and probe cell-cell interactions during innate immune responses and wound healing using zebrafish as a model system. We are also using human iPS derived neutrophils to engineer cells for better anti-microbial and anti-tumor function.

Selected References
  1. Yoo SK, Starnes TW, Deng Q, Huttenlocher A. Lyn is a redox sensor that mediates leukocyte wound attraction in vivo. Nature. 2011 Nov 20;480(7375):109-12. PMID: 22101434; PMCID: PMC3228893.
  2. de Oliveira S, Rosowski EE, Huttenlocher A. Neutrophil migration in infection and wound repair: going forward in reverse. Nat Rev Immunol. 2016 May 27;16(6):378-91. Review. PubMed PMID: 27231052; PMCID: PMC5367630.
  3. LeBert D, Squirrell JM, Freisinger C, Rindy J, Golenberg N, Frecentese G, Gibson A, Eliceiri KW, Huttenlocher A. Damage-induced reactive oxygen species regulate vimentin and dynamic collagen-based projections to mediate wound repair. Elife. 2018 Jan 16;7. pii: e30703. PMID: 29336778; PMCID: PMC5790375.
  4. Miskolci V, Squirrell J, Rindy J, Vincent W, Sauer JD, Gibson A, Eliceiri KW, Huttenlocher A. Distinct inflammatory and wound healing responses to complex caudal fin injuries of larval zebrafish. Elife. 2019 Jul 1;8. pii: e45976. PMID: 31259685; PMCID: PMC6602581.
  5. Brok-Volchanskaya VS, Bennin DA, Suknuntha K, Klemm LC, Huttenlocher A, Slukvin I. (2019) Effective and rapid generation of functional neutrophils from induced pluripotent stem cells using ETV2- modified mRNA. Stem Cell Reports. 2019 Nov 5. pii: S2213-6711(19)30368-6.