Troy Hornberger, PhD

Credentials: Comparative Biosciences

Position title: Professor - Comparative Biosciences, University of Wisconsin - Madison

Email: troy.hornberger@wisc.edu

Phone: 608-695-2847

Organ System/Disease Focus
Skeletal muscle growth and regeneration
Aligned Research Focus
Musculoskeletal Regeneration

https://www.vetmed.wisc.edu/lab/hornberger/

Research Description

A portion of my labs research uses mouse models to understand the factors that regulate the regenerative capacity of skeletal muscle. For instance, we recently created mice with satellite cell-specific and inducible knockout of a protein called TRIM28 and found that the skeletal muscles of these mice are unable to regenerate after a destructive injury. Our current efforts are now focused on defining how TRIM28 exerts this powerful regulatory function.

Selected References:
  1. Jorgenson KW, Phillips SM, Hornberger TA. Identifying the Structural Adaptations that Drive the Mechanical Load-Induced Growth of Skeletal Muscle: A Scoping Review.Cells. 2020 Jul 9;9(7):1658. doi: 10.3390/cells9071658.
  2. You JS, McNally RM, Jacobs BL, Privett RE, Gundermann DM, Lin KH, Steinert ND, Goodman CA, Hornberger TA. The role of raptor in the mechanical load-induced regulation of mTOR signaling, protein synthesis, and skeletal muscle hypertrophy.FASEB J. 2019 Mar;33(3):4021-4034. doi: 10.1096/fj.201801653RR.
  3. You JS, Dooley MS, Kim CR, Kim EJ, Xu W, Goodman CA, Hornberger TA. A DGKζ-FoxO-ubiquitin proteolytic axis controls fiber size during skeletal muscle remodeling. Sci Signal. 2018 May 15;11(530):eaao6847. doi: 10.1126/scisignal.aao6847.
  4. Watt KI, Goodman CA, Hornberger TA, Gregorevic P. The Hippo Signaling Pathway in the Regulation of Skeletal Muscle Mass and Function. Exerc Sport Sci Rev. 2018 Apr;46(2):92-96. doi: 10.1249/JES.0000000000000142.
  5. Potts GK, McNally RM, Blanco R, You JS, Hebert AS, Westphall MS, Coon JJ, Hornberger TA. A map of the phosphoproteomic alterations that occur after a bout of maximal-intensity contractions. J Physiol. 2017 Aug