Troy Hornberger, PhD

https://www.vetmed.wisc.edu/lab/hornberger/

Research Description

A portion of my labs research uses mouse models to understand the factors that regulate the regenerative capacity of skeletal muscle. For instance, we recently created mice with satellite cell-specific and inducible knockout of a protein called TRIM28 and found that the skeletal muscles of these mice are unable to regenerate after a destructive injury. Our current efforts are now focused on defining how TRIM28 exerts this powerful regulatory function.

Selected References:

1. Zhu WG, Hibbert JE, Lin KH, Steinert ND, Lemens JL, Jorgenson KW, Newman SM, Lamming DW, Hornberger TA. Weight Pulling: A Novel Mouse Model of Human Progressive Resistance Exercise. Cells, 2021 Sep 17;10(9):2459. PMCID: PMC8465477
2. Steinert ND, Potts GK, Wilson GM, Klamen AM, Lin KH, Hermanson JB, McNally RM, Coon JJ, Hornberger TA. Mapping of the Contraction-Induced Phosphoproteome Identifies TRIM28 as a Significant Regulator of Skeletal Muscle Size and Function. Cell Reports. 2021 Mar 2;34(9): 108796.
3. Jorgenson KW, Phillips SM, Hornberger TA. Identifying the Structural Adaptations that Drive the Mechanical Load-Induced Growth of Skeletal Muscle: A Scoping Review.Cells. 2020 Jul 9;9(7):1658. doi: 10.3390/cells9071658.
4. You JS, McNally RM, Jacobs BL, Privett RE, Gundermann DM, Lin KH, Steinert ND, Goodman CA, Hornberger TA. The role of raptor in the mechanical load-induced regulation of mTOR signaling, protein synthesis, and skeletal muscle hypertrophy.FASEB J. 2019 Mar;33(3):4021-4034. doi: 10.1096/fj.201801653RR.
5. You JS, Dooley MS, Kim CR, Kim EJ, Xu W, Goodman CA, Hornberger TA. A DGKζ-FoxO-ubiquitin proteolytic axis controls fiber size during skeletal muscle remodeling. Sci Signal. 2018 May 15;11(530):eaao6847. doi: 10.1126/scisignal.aao6847.