Ying Ge, PhD

Pubmed

More information:

• Ge Research Group
• Ying Ge’s Cell and Regenerative Biology homepage

Research Description:

My research aims to understand the molecular and cellular mechanisms underlying cardiovascular diseases via novel systems biology approaches in conjunction with functional studies. Specifically, in cardiac regenerative biology and medicine, we aim to evaluate the efficacy of stem cell therapies for the treatment of heart failure using integrated proteomics and metabolomics approaches and to understand the paracrine signaling mechanism in cardiac regeneration. My research is highly interdisciplinary within the interface of chemistry, biology, and medicine. Success in our research will foster the development of new strategies for early diagnosis, prevention and better treatment of cardiovascular diseases.

Selected References:

• Tucholski, T.; Cai, W.; Gregorich, Z.R.; Bayne, E.F.; Mitchell, S.D.; McIlwain, S.J.; de Lange, W.J.; Wrobbel, M.; Karp, H.; Hite, Z.; Vikhorev, P.G.; Marston, S.B.; Lal, S.; Li, A.; dos Remedios, C.; Kohmoto, T.; Hermsen, J.; Ralphe, J.C.; Kamp, T.J.; Moss, R.L.; Ge, Y. Distinct hypertrophic cardiomyopathy genotypes result in convergent sarcomeric proteoform profiles revealed by top-down proteomics, Proc Natl Acad Sci USA, 2020, 117 (40), 24691-24700. Article.
• Brown, K. A.; Chen, B.; Guardado-Alvarez, T. M.; Lin, Z.; Hwang, L.; Ayaz-Guner, S.; Jin, S.; Ge, Y. A Photocleavable Surfactant for Top-Down Proteomics, Nature Methods. 2019, 16, 417-420. Article. News Release.
• Tiambeng, T. N.*; Roberts, D. S.*; Brown, K.A.; Zhu, Y.; Chen, B.; Wu, Z.; Mitchell, S. D.; Guardado-Alvarez, T.M.; Jin, Y.; Ge, Y. Nanoproteomics enables proteoform-resolved analysis of low-abundance proteins in human serum., Nat Commun., 2020, 11 (1), 1-12. Article.
• Cai, W.; Zhang, J.; De Lange, W. J.; Gregorich, Z. R.; Karp, H.; Ferrell, E. T.; Mitchell, S. T.; Tucholski, T.; Lin, Z.; Biermann, M.; McIlwain, S.; Ralphe, J. C.; Kamp, T. J.; Ge, Y. Unbiased Proteomics Method to Assess the Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes., Circ Res., 2019, 125, 936–953. Article.
• Bayne, E.B.; Simmons, A.D.; Roberts, D.S.; Zhu, Y.; Aballo, T.A.; Wancewicz, B.; Palecek, S.P.; Ge, Y. Multiomics Method Enabled by Sequential Metabolomics and Proteomics for Human Pluripotent Stem-Cell Derived Cardiomyocytes J. Proteome Res., 2021, 20, 10, 4646-4654. Article.

   

PubMed Link:

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http://www.ncbi.nlm.nih.gov/pubmed?term=Ge%2C%20Ying%2Cwisconsin