Ying Ge, PhD
Position title: Associate Professor, Cell and Regenerative Biology
- Organ System/Disease Focus:
- Cardiovascular disease
My research aims to understand the molecular and cellular mechanisms underlying cardiovascular diseases via novel systems biology approaches in conjunction with functional studies. Specifically, in cardiac regenerative biology and medicine, we aim to evaluate the efficacy of stem cell therapies for the treatment of heart failure using integrated proteomics and metabolomics approaches and to understand the paracrine signaling mechanism in cardiac regeneration. My research is highly interdisciplinary within the interface of chemistry, biology, and medicine. Success in our research will foster the development of new strategies for early diagnosis, prevention and better treatment of cardiovascular diseases.
- Cai, W.; Tucholski, T. M.; Gregorich Z. R.; Ge, Y. Top-down proteomics: technology advancements and application to heart diseases, Expert Rev. Proteomics, 2016, 13, 717-730. Doi: 10.1080/14789450.2016.1209414 ·
- Chang, Y.; Ye, L.; Cai, W.; Lee, Y-K.; Guner, H.; Lee, Y-S.; Kamp, T. J.; Zhang, J.; Ge, Y. Quantitative proteomics reveals differential regulation of protein expression in recipient myocardium after trilineage cardiovascular cell transplantation, Proteomics, 2015, 15, 2560-2567. ·
- Hwang, L.; Ayaz-Guner, S.; Cai, W.; Gregorich Z. R.; Jin, S.; Ge, Y. Specific enrichment of phosphoproteins using functionalized multivalent nanoparticles, J. Am. Chem. Soc., 2015, 137, 2432-2435. ·
- Ye, L.; Chang, Y. H.; Xiong Q.; Zhang P.; Somasundaram, P.; Lepley M.; Swingen C.; Su, L.; Wendel, J. S.; Guo, J.; Jang, A.; Rosenbush, D.; Zhang, L.; Greder, L.; Dutton, J. R.; Zhang, J.; Kamp, T. J.; Kaufman, D.S.; Ge, Y.; Zhang, J. Cardiac repair in a porcine model of acute myocardial infarction with human induced pluripotent stem cell-derived cardiovascular cells, Cell Stem Cell, 2014, 15, 750-761. ·
- Ge, Y.; Rybakova, I.; Xu, Q.; Moss, R. L. Top-down high resolution mass spectrometry of cardiac myosin binding protein C revealed that truncation alters protein phosphorylation state, Proc. Natl. Acad. Sci. U. S. A. 2009,106, 12658-12663.
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