Wendy C. Crone, PHD

Pubmed

More information:

• Crone Laboratory Home Page

Research Description:

Our group draws upon expertise in experimental mechanics, biomedical engineering, and materials science to investigate topics connected to biotechnology, biomaterials, and therapeutic medical devices. By developing device fabrication techniques, conducting materials characterization on a wide range of natural and polymeric materials for engineered systems, and using microscopy techniques for the measurement of cell/cell and cell/substrate mechanical interactions, our work has impacted stem cell science and engineering research. For example, our group has designed and fabricated cell culture platforms that are highly adaptable and relevant to fundamental research, drug discovery, and toxicity testing.

Featured Research: New model will help researchers connect dots at the intersection of our joints

Selected References:

• • Mitchell Josvai, Erzsebet Polyak; Meghana Kalluri, Samantha Robertson, Wendy C Crone, Masatoshi Suzuki, “An engineered in vitro model of the human myotendinous junction,” Acta Biomaterialia (2024). https://doi.org/10.1016/j.actbio.2024.04.007
  • Alana Stempien, Mitchell Josvai, Jacob Notbohm, Jianhua Zhang, Timothy J Kamp, Wendy C Crone, “Influence of Remodeled ECM and Co-Culture with iPSC-Derived Cardiac Fibroblasts on the Mechanical Function of Micropatterned iPSC-derived Cardiomyocytes,” Cardiovascular Engineering and Technology (2024). https://doi.org/10.1007/s13239-024-00711-8
  • C. Ralphe, W. De Lange, R. Moss, E. Farrell, W.C. Cone, J. Hernandez, A. Stempien, C. Kreitzer, D. Petty, D. Jacobs, “cMyBP-C Ablation in Human Engineered Cardiac Tissue Causes Progressive Ca2+-Handling Abnormalities,” Journal of General Physiology, 155: 4 (2023).
  • Reilly, S. Munawar, J. Zhang, W.C. Crone, L.L. Eckhardt, “Challenges and innovation: Disease modeling using human-induced pluripotent stem cell-derived cardiomyocytes,” Front. Cardiovasc. Med. 9:966094 (2022). doi: 10.3389/fcvm.2022.966094  PMID: 36035948
  • Stempien, M. Josvai, W.J. de Lange, J.J. Hernandez, J. Notbohm, T.J. Kamp, H.H. Valdivia, L.L. Eckhardt, K.R. Maginot, J.C. Ralphe, W.C. Crone, “Identifying Features of Cardiac Disease Phenotypes based on Mechanical Function in a Catecholaminergic Polymorphic Ventricular Tachycardia Model,” Front. Bioeng. Biotechnol. 10 (2022). https://doi.org/10.3389/fbioe.2022.873531 PMID: 35620470
  • N. Napiwocki, A. Stempien, D. Lang, R.A. Kruepke, G. Kim, J. Zhang, L.L. Eckhardt, A.V. Glukhov, T.J. Kamp, W.C. Crone, “Micropattern Platform Promotes Extracellular Matrix Remodeling by Human PSC-derived Cardiac Fibroblasts and Enhances Contractility of Co-cultured Cardiomyocytes,” Physiological Reports (2021). http://doi.org/10.14814/phy2.15045
  • N. Napiwocki, D. Lang, A. Stempien, J. Zhang, R. Vaidyanathan, J.C. Makielski, L.L. Eckhardt, A.V. Glukhov, T.J. Kamp, W.C. Crone, “Aligned human cardiac syncytium for in vitro analysis of electrical, structural, and mechanical readouts,” Biotechnology and Bioengineering, 118, 442–452 (2021). DOI: 10.1002/bit.27582  PMID: 32990953