Qiang Chang, PHD
Associate Professor, Med Genetics / Neurology; Director, Waisman Center
Organ System/Disease Focus:
Neurodevelopmental diseases, Rett Syndrome
Aligned Research Focus:
Basic Stem Cell Science
Biography
Member of the SCRMC Neural Regeneration Focus Group
More information:
Research Description:
We use various forms of gene targeting in mouse embryonic stem cells to generate genetically engineered mouse lines. One major focus of our lab is to use these mutant mice as animal models for human diseases, which allows us to study the molecular mechanism of diseases in vivo. In addition, we are beginning to explore the role of DNA methylation-dependent epigenetic regulatory mechanism in adult neurogenesis. Most recently, we have generated disease-specific induced pluripotent stem (iPS) cells from several Rett syndrome (RTT) patients. We plan to use these RTT iPS cells as a tissue culture based human model of the disease for understanding its pathogenesis and screening for drugs.
Featured Researcher in Fall 2010 SCRMC Newsletter