Christian Capitini, MD
Position title: Associate Professor, Pediatrics
- Organ System/Disease Focus:
- Graft-versus-tumor effect for pediatric malignancies/GVHD
- Aligned Research Focus:
- Allogeneic hematopoietic stem cell transplant
- Society for Immunotherapy of Cancer announces officers, at-large directors | July 12, 2020
- NCI Announces Support for Research in Cell-based Immunotherapies of Human Cancer | Sept. 23, 2019
- Against the odds: For children with resistant leukemia, immunotherapy offers hope | May 21, 2018
Dr. Capitini leads an NIH-supported laboratory focusing on development of cell-based therapies, including NK cells and CAR T cells, for the treatment of childhood cancers like neuroblastoma and osteosarcoma. The laboratory also manufactures alternatively activated macrophages for complications of hematopoietic stem cell transplant, like graft-versus-host-disease and acute radiation syndrome. In the clinic, Dr. Capitini was a site Principal Investigator for the first multi-center CAR T cell trial, which led to FDA approval of tisagenlecleucel (Kymriah) for the treatment of recurrent/refractory B cell leukemia in children. He remains a site PI for trials testing Kymriah as upfront therapy for high risk B cell leukemias and for treatment of relapsed non-Hodgkin lymphoma.
- Cho MM, Quamine AE, Olsen MR, Capitini CM: Programmed death protein-1 on NK cells, Fact or Fiction? Journal for Clinical Investigation, 2020 Jun 1;130(6):2816-2819.
- Shankar K, Capitini CM*, Saha K*: Genome Engineering of Induced Pluripotent Stem Cells to Manufacture Natural Killer Cell Therapies. Stem Cell Research and Therapy 2020, Jun 16;11(1):234. PMCID: PMC7298853.
- Damodharan SN, Walker KL, Forsberg MH, McDowell KA, Bouchlaka MN, Drier DA, Sondel PM, DeSantes KB, Capitini CM: Analysis of ex vivo expanded and activated clinical grade human NK cells after cryopreservation. Cytotherapy 2020 Aug;22(8):450-457.
- Chinnadurai R, Forsberg MH, Kink J, Hematti P, Capitini CM: Use of MSCs and MSC-educated macrophages to mitigate hematopoietic acute radiation syndrome. Current Stem Cell Reports, 2020 Sep;6(3):77-85.
- D’Souza SS, Bennett S, Kumar A, Kelnhofer LE, Weinfurter J, Suknuntha K, Coonen J, Meija A, Simmons H, Golos T, Hematti P, Capitini CM, Reynolds M, Slukvin I: Transplantation of TCRa/b-depleted allogeneic bone marrow in nonhuman primates. Experimental Hematology 2020 Nov 8:S0301-472X(20)30563-4.