Christian Capitini, MD

Position title: Associate Professor, Pediatrics

Email: ccapitini@pediatrics.wisc.edu

Phone: 608-262-2415

Organ System/Disease Focus:
Graft-versus-tumor effect for pediatric malignancies/GVHD
Aligned Research Focus:
Allogeneic hematopoietic stem cell transplant
Christian Capitini headshot

Pubmed

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Research Description:

Dr. Capitini leads an NIH-supported laboratory focusing on development of cell-based therapies, including NK cells and CAR T cells, for the treatment of childhood cancers like neuroblastoma and osteosarcoma. The laboratory also manufactures alternatively activated macrophages for complications of hematopoietic stem cell transplant, like graft-versus-host-disease and acute radiation syndrome. In the clinic, Dr. Capitini was a site Principal Investigator for the first multi-center CAR T cell trial, which led to FDA approval of tisagenlecleucel (Kymriah) for the treatment of recurrent/refractory B cell leukemia in children. He remains a site PI for trials testing Kymriah as upfront therapy for high risk B cell leukemias and for treatment of relapsed non-Hodgkin lymphoma.

Selected References:
  • Cho MM, Quamine AE, Olsen MR, Capitini CM: Programmed death protein-1 on NK cells, Fact or Fiction? Journal for Clinical Investigation, 2020 Jun 1;130(6):2816-2819.
  • Shankar K, Capitini CM*, Saha K*: Genome Engineering of Induced Pluripotent Stem Cells to Manufacture Natural Killer Cell Therapies. Stem Cell Research and Therapy 2020, Jun 16;11(1):234. PMCID: PMC7298853.
  • Damodharan SN, Walker KL, Forsberg MH, McDowell KA, Bouchlaka MN, Drier DA, Sondel PM, DeSantes KB, Capitini CM: Analysis of ex vivo expanded and activated clinical grade human NK cells after cryopreservation. Cytotherapy 2020 Aug;22(8):450-457.
  • Chinnadurai R, Forsberg MH, Kink J, Hematti P, Capitini CM: Use of MSCs and MSC-educated macrophages to mitigate hematopoietic acute radiation syndrome. Current Stem Cell Reports, 2020 Sep;6(3):77-85.
  • D’Souza SS, Bennett S, Kumar A, Kelnhofer LE, Weinfurter J, Suknuntha K, Coonen J, Meija A, Simmons H, Golos T, Hematti P, Capitini CM, Reynolds M, Slukvin I: Transplantation of TCRa/b-depleted allogeneic bone marrow in nonhuman primates. Experimental Hematology 2020 Nov 8:S0301-472X(20)30563-4.