Matthew E. Brown, PhD
Position title: Assistant Professor, Surgery/Transplant
Email: brownm@surgery.wisc.edu
Phone: 608-263-1727
- Organ System/Disease Focus
- Cardiovascular System, Transplantation, Cancer
- Aligned Research Focus
- Human and Non-human Primate Transplantation Immunology/Stem Cell Biology
More Information:
Research Description:
The Brown Lab focuses on exploring the nexus of pluripotent stem cell biology and immunology. We are currently investigating the mechanisms underpinning the immune response to autologous and allogeneic pluripotent stem cell (PSC)-derived cell therapies. Using transplantation immunology and genomics-based strategies, in conjunction with humanized mouse models, our goals are to 1) improve traditional organ transplantation outcomes, 2) gain new insights into PSC biology and immunology, and 3) enable curative regenerative medicine therapies.
Selected References:
- Jiwon Seo, Sayandeep Saha, Matthew E. Brown, The past, present, and future promise of pluripotent stem cells,
Journal of Immunology and Regenerative Medicine, Volumes 22–23, 2024, 100077, ISSN 2468-4988, https://doi.org/10.1016/j.regen.2024.100077.
(https://www.sciencedirect.com/science/article/pii/S2468498824000015) - , , , et al. Robust engraftment of fetal nonhuman primate CD34-positive cells in immune-deficient mice. J Leukoc Biol. 2022; 00 1– 11. 10.1002/JLB.5TA0921-481RR
- Hermsen J, Brown ME. Humanized Mouse Models for Evaluation of PSC Immunogenicity. Curr Protoc Stem Cell Biol. 2020 Sep;54(1):e113. doi: 10.1002/cpsc.113. PMID: 32588980; PMCID: PMC7436941.
- Brown ME, Zhou Y, McIntosh BE, Norman IG, Lou HE, Biermann M, Sullivan JA, Kamp TJ, Thomson JA, Anagnostopoulos PV, Burlingham WJ. A Humanized Mouse Model Generated Using Surplus Neonatal Tissue. Stem cell reports. 2018; 10(4):1175-1183.PubMed [journal]PMID:29576539PMCID:PMC5998340
- Zhang J, Chu LF, Hou Z, Schwartz MP, Hacker T, Vickerman V, Swanson S, Leng N, Nguyen BK, Elwell A, Bolin J, Brown ME, Stewart R, Burlingham WJ, Murphy WL, Thomson JA. Functional characterization of human pluripotent stem cell-derived arterial endothelial cells. Proceedings of the National Academy of Sciences of the United States of America. 2017; 114(30):E6072-E6078. PubMed [journal]PMID:28696312PMCID:PMC5544294
- Sackett SD, Brown ME, Tremmel DM, Ellis T, Burlingham WJ, Odorico JS. Modulation of human allogeneic and syngeneic pluripotent stem cells and immunological implications for transplantation. Transplantation reviews (Orlando, Fla.). 2016; 30(2):61-70. NIHMSID: NIHMS768239PubMed [journal]PMID:26970668PMCID:PMC4859756
- McIntosh BE, Brown ME, Duffin BM, Maufort JP, Vereide DT, Slukvin II, Thomson JA. Nonirradiated NOD,B6.SCID Il2rγ-/- Kit(W41/W41) (NBSGW) mice support multilineage engraftment of human hematopoietic cells. Stem cell reports. 2015; 4(2):171-80.PubMed [journal]PMID:25601207PMCID:PMC4325197
- Rajesh D, Dickerson SJ, Yu J, Brown ME, Thomson JA, Seay NJ. Human lymphoblastoid B-cell lines reprogrammed to EBV-free induced pluripotent stem cells. Blood. 2011; 118(7):1797-800. PubMed [journal]PMID:21708888PMCID:PMC4081297