Stem Cell & Regenerative Medicine Center
University of Wisconsin – Madison

William (Bill) Bement, PhD

Credentials: Center for Quantitative Cell Imaging; Department of Integrative Biology

Position title: Director/Professor

Email: wmbement@wisc.edu

Phone: 608-215-5918

Organ System/Disease Focus
Muscular Dystrophy
Aligned Research Focus
Cell Repair

http://bement.molbio.wisc.edu/

Research Description

Our lab studies cell division and cell repair in the Xenopus laevis (clawed frog) system. We are particularly interested in how cells coordinate signaling and cytoskeletal dynamics in the cell cortex. During cell division, cells somehow link the position of the mitotic spindle to the cortical signals needed to specify formation of the cytokinetic apparatus such that the cell divides with the proper orientation, a behavior that is essential for the maintenance of stem cell populations. During repair, cells somehow transduce cell damage into a rapid, tightly choreographed series of signaling events and cytoskeletal reorganization, a behavior that is essential for the health and longevity of all cell types, including stem cells.

Selected References
  1. A versatile cortical pattern-forming circuit based on Rho, F-actin, Ect2, and RGA-3/4. Michaud A, Leda M, Swider ZT, Kim S, He J, Landino J, Valley JR, Huisken J, Goryachev AB, von Dassow G,Bement WM.J Cell Biol. 2022 Aug 1;221(8):e202203017. doi: 10.1083/jcb.202203017. Epub 2022 Jun 16. PMID: 35708547
  2. Cell cycle and developmental control of cortical excitability in Xenopus laevis. Swider ZT, Michaud A, Leda M, Landino J, Goryachev AB, Bement WM.Mol Biol Cell. 2022 Jul 1;33(8):ar73. doi: 10.1091/mbc.E22-01-0025. Epub 2022 May 20. PMID: 35594176
  1. Rho and F-actin self-organize within an artificial cell cortex. Landino J, Leda M, Michaud A, Swider ZT, Prom M, Field CM, Bement WM, Vecchiarelli AG, Goryachev AB, Miller AL.Curr Biol. 2021 Dec 20;31(24):5613-5621.e5. doi: 10.1016/j.cub.2021.10.021. Epub 2021 Nov 4. PMID: 34739819
  1. Cross-talk-dependent cortical patterning of Rho GTPases during cell repair. Moe A, Holmes W, Golding AE, Zola J, Swider ZT, Edelstein-Keshet L, Bement W.Mol Biol Cell. 2021 Aug 1;32(16):1417-1432. doi: 10.1091/mbc.E20-07-0481. Epub 2021 Jun 16.PMID: 34133216
  1. Cortical excitability and cell division. Michaud A, Swider ZT, Landino J, Leda M, Miller AL, von Dassow G, Goryachev AB, Bement WM. Curr Biol. 2021 May 24;31(10):R553-R559. doi: 10.1016/j.cub.2021.02.053.   PMID: 34033789
  1. Plasma membrane integrity: implications for health and disease. Ammendolia DA, Bement WM , Brumell JH. BMC Biol. 2021 Apr 13;19(1):71. doi: 10.1186/s12915-021-00972-y. PMID: 33849525
  2. Extraction of active RhoGTPases by RhoGDI regulates spatiotemporal patterning of RhoGTPases.Golding AE, Visco I, Bieling P, Bement WM. Elife. 2019 Oct 24;8:e50471. doi: 10.7554/eLife.50471. PMID: 31647414
  3. Spindle-F-actin interactions in mitotic spindles in an intact vertebrate epithelium. Kita AM, Swider ZT, Erofeev I, Halloran MC, Goryachev AB, Bement WM.
    Mol Biol Cell. 2019 Jul 1;30(14):1645-1654. doi: 10.1091/mbc.E19-02-0126. Epub 2019 May 15.
    PMID: 31091161
  4. An interaction between myosin-10 and the cell cycle regulator Wee1 links spindle dynamics to mitotic progression in epithelia. Sandquist JC, Larson ME, Woolner S, Ding Z, Bement WM. J Cell Biol. 2018 Mar 5;217(3):849-859. doi: 10.1083/jcb.201708072. Epub 2018 Jan 10. PMID: 29321170
  5. Membrane dynamics during cellular wound repair. Davenport NR, Sonnemann KJ, Eliceiri KW, Bement WM. Mol Biol Cell. 2016 July 15: 27 (14) 2272-85. doi:10.1091/mbc.E16-04-0223. Epub 2016 May 25