Title: Environmental Regulation of Intestinal Epithelial Function: Insights from Organoid Models
Abstract: The intestinal epithelium is continuously exposed to environmental signals derived from the microbiota, immune system, and host metabolic pathways. These signals influence epithelial renewal, differentiation, and barrier function, yet the mechanisms by which they regulate epithelial biology remain incompletely understood. Intestinal organoid systems provide a powerful platform to investigate how environmental factors shape epithelial responses in a controlled setting. In this seminar, I will discuss how organoid-based models are used to study environmental regulation of intestinal epithelial function, focusing on three areas: microbial bile acids and their effects on epithelial signaling, interactions between macrophages and epithelial spheroids that model immune-epithelial crosstalk, and bile acid-dependent FXR signaling pathways that influence epithelial differentiation. Together, these studies highlight how environmental cues modulate intestinal epithelial biology and demonstrate the utility of organoid systems for dissecting complex host-environment interactions.
Join Zoom Meeting
https://uwmadison.zoom.us/j/91814162149?pwd=AYgwgbFNekOLHyQrj7wUCkxem9b2Yw.1
Meeting ID: 918 1416 2149
Passcode: 970506