Title: Hb-EGF-mobilized epicardial cells direct cardiomyocyte proliferation dynamics during heart morphogenesis and regeneration
Abstract: Unlike adult mammals, which have limited capacity for cardiac regeneration, adult zebrafish can replace lost or damaged heart tissue and restore organ function. The outer layer of the heart, called the epicardium, undergoes rapid, massive expansion upon cardiac injury. Epicardial tissue has several documented pro-regenerative roles, including the regulation of cardiomyocyte division, but there is no single factor identified that direct its initial dynamic response. Here, we identify Heparin-binding EGF-like growth factor (Hb-EGF), an EGF receptor ligand, as a highly potent, instructive mitogen for epicardial subpopulations, enhancing their ability to instruct ventricular muscle formation at the juvenile stage and muscle regeneration upon cardiac damage.
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