Seminar Lab Series with speaker Margot Amitrano

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Discovery Building, DeLuca Forum
@ 12:00 pm
https://stemcells.wisc.edu/stem-cell-seminar-lab-series/

Title: Synthetic hydrogels for iPSC-derived cardiomyocyte differentiation and maturation

Abstract: By combining high-throughput screening and optimization modeling, our work has identified optimized, fully-defined substrates specific for iPSC-derived cardiomyocyte (iPSC-CM) differentiation and maturation. We developed poly(ethylene glycol) (PEG) hydrogels that present a range of stiffnesses, as well as various synthetic adhesion ligands. All PEG hydrogels supported robust and reproducible levels of iPSC-CM differentiation. Over only two rounds of screening, we identified two hydrogel formulations which significantly improved iPSC-CM maturation. We then studied the addition of another substrate variable, surface topography, to assess its potential compounded influence on iPSC-CM differentiation and maturation. The identified substrates could be applied to boost progress in disease modeling or drug screening applications.

Our Seminar Lab Series will be offered in hybrid format:

The in-person seminar is each Tuesday during the semester from noon-1 p.m. at the Discovery Building, DeLuca Forum.

To join online, please click the zoom link below:
https://uwmadison.zoom.us/j/96958883460
*if you are asked for a passcode: 970506