Title: Girk3 in bone development and disease
Abstract: Musculoskeletal issues are among the top reasons that patients visit their doctors in the United States, particularly with aging. Despite their prevalence, there are still significant treatment gaps in regenerative therapies for bone tissue (i.e., bone anabolics) and there are currently no disease-modifying osteoarthritis drugs available for clinical use. G protein-gated inwardly rectifying K+ channel 3 is a promising molecular target for bone and cartilage regeneration, as Girk3 deletion induces bone formation and preserves cartilage during osteoarthritis progression in murine orthopedic models. Underlying these phenotypes is a common mesenchymal progenitor cell, which is more proliferative in Girk3-/- animals compared to controls. Elucidation of the role of Girk3 in mesenchymal progenitor cell proliferation could define a novel treatment target for musculoskeletal disease.
Our Seminar Lab Series will be offered in hybrid format:
The in-person seminar is each Tuesday during the semester from noon-1 p.m. at the Discovery Building, DeLuca Forum.
To join online, please click the zoom link below:
https://uwmadison.zoom.us/j/96958883460
*if you are asked for a passcode: 970506