Title: Cellular therapy for treatment of radiation-induced salivary dysfunction – preclinical to Phase I studies
Abstract: Radiation damage to salivary glands is a significant side effect of head and neck cancer radiation. Damage results in loss of glandular architecture leading to dysfunctional saliva. Using a mouse model of radiation induced salivary dysfunction, we have developed a cellular therapy approach to restore salivary function using mesenchymal stromal cells. Pilot studies in head and neck cancer patients confirmed the ability to generate an autologous cell therapy and a first-in-human study suggested safety of the approach. An ongoing Phase I study is investigating the safety and tolerability of this approach in head and neck cancer patients.
Our Seminar Lab Series will be offered in hybrid format:
The in-person seminar is each Tuesday during the semester from noon-1 p.m. at the Discovery Building, Orchard View!
To join online, please click the zoom link below:
https://uwmadison.zoom.us/j/96958883460
*if you are asked for a passcode: 970506