Title: Above the genome: post-transcriptional mechanisms that guide stem cell biology
Abstract: The enormous scientific and therapeutic power of stem cells lies in their remarkable ability to give rise to diverse, functionally mature cells through a process called differentiation. Starting with a single cell, the zygote, differentiation generates all cell types in the body without altering DNA content. Thus, a hair follicle cell from one individual contains essentially the same genetic material as a mucus-secreting intestinal cell from the same person. Together, this implies that powerful and intricate regulation exists to interpret the genome in different ways during development. In a laboratory or clinical setting, stem cells can likewise be directed to produce desired cell types for transplantation, disease modeling, and drug testing; however, we have not yet realized this potential because we do not fully understand the regulatory mechanisms that instruct differentiation. In this talk, I will highlight work that our lab has done to define regulatory mechanisms in controlling development and tissue homeostasis.
Our Seminar Lab Series will be offered in hybrid format:
The in-person seminar is each Tuesday during the semester from noon-1 p.m. at the Discovery Building, DeLuca Forum.
To join online, please click the zoom link below:
https://uwmadison.zoom.us/j/96958883460
*if you are asked for a passcode: 970506