Title: Metabolic Modulation to Minimize Graft-versus-host Disease and Promote Anti-cancer Immunity
Abstract: Metabolic reprogramming represents a dynamic process during the evolution of in vivo T cell responses. In the presented studies, I will highlight the role of the cellular energy sensor, AMP-activated protein kinase (AMPK), in T cells during the development of graft-versus-host disease. I will then describe how this novel metabolic information can be used both to reduce the incidence and severity of GVHD, but also to facilitate and enhance anti-cancer immune responses. In total, the presented findings will emphasize the importance of deepening our knowledge of in vivo T cell metabolism and the therapeutic advantages that can be wielded once such information has been acquired.
Our Seminar Lab Series will be offered in hybrid format:
The in-person seminar is each Tuesday during the semester from noon-1 p.m. at the Discovery Building, DeLuca Forum.
To join online, please click the zoom link below:
https://uwmadison.zoom.us/j/96958883460
*if you are asked for a passcode: 970506