Title: The ASPIRO Trial: Development of an Autologous, iPSC-based Neuron Replacement Cell Therapy for Parkinson’s Disease
Abstract: Parkinson’s disease is a neurodegenerative disorder involving the loss of dopaminergic neurons in the substantia nigra. Aspen Neuroscience has developed an autologous, iPSC-based cell therapy to replace lost neurons by injection of dopaminergic precursor cells into the striatum. The phase 1b/2a clinical trial was initiated in early 2024 and recently completion of dosing for the first cohort was announced. This talk will cover the preclinical development program including development of innovative bioinformatic tools as well as the collaboration on an IND-enabling NHP delivery and safety study with Professor Marina Emborg from the University of Wisconsin-Madison.
Our Seminar Lab Series will be offered in hybrid format:
The in-person seminar is each Tuesday during the semester from noon-1 p.m. at the Discovery Building, DeLuca Forum.
To join online, please click the zoom link below:
https://uwmadison.zoom.us/j/96958883460
*if you are asked for a passcode: 970506