Kristyn S. Masters, PHD
Position title: Professor. Biomedical Engineering
- Organ System/Disease Focus:
- Cardiovascular development and disease.
- Aligned Research Focus:
- Heart Valve Tissue Engineering and Angiogenesis.
Dr. Masters performs research in the area of biomaterials and tissue engineering, with a specific focus on using tissue engineering approaches to: 1) better understand the etiology of cardiovascular diseases such as aortic valve calcification, and 2) characterize the role of the cellular microenvironment in guiding cellular decision-making, with specific applications in dermal wound healing, angiogenesis, age-related macular degeneration, and cancer. Through these investigations, we hope to discover new targets for therapeutic intervention, as well as develop personalized medicine approaches by identifying types of patients would be most likely to benefit from a specific therapy.
- Laperle A, Hsiao C, Lampe M, Mortier J, Saha K, Palecek SP, Masters KS*. α-5 Laminin Synthesized by Human Pluripotent Stem Cells Promotes Self-Renewal. Stem Cell Rep, 2015; 5:195-206.
- Porras AM, Hutson HN, Berger AJ, Masters KS*. Engineering approaches to study fibrosis in 3-D in vitro systems. Curr Opin Biotechnol, 2016; 40: 24-30.
- Porras AM, Westlund JA, Evans AD, Masters KS*. Creation of Disease-Inspired Biomaterial Environments to Mimic Pathological Events in Early Calcific Aortic Valve Disease. Proc Natl Acad Sci USA, 2018; 115:E363-E371.
Kreeger PK*, Strong LE, Masters KS*. Engineering approaches to study cellular decision-making. Ann Rev Biomed Engin. 2018; 20:49–72. (PMC6327838)
Berger AJ, Renner CM, Hale I, Yang X, Ponik SM, Weisman PS, Masters KS*, Kreeger PK*. Scaffold stiffness influences breast cancer cell invasion via EGFR-linked Mena upregulation and matrix remodeling. Matrix Biol, 2019; In Press. doi: 10.1016/j.matbio.2019.07.006 (PMCID in progress)