Randall J Kimple, MD, PhD, MBA, FASTRO
Position title: Associate Professor, Human Oncology
- Organ System/Disease Focus
- Head and neck cancer, salivary biology
- Aligned Research Focus
- Use of mesenchymal stromal cells for treatment and prevention of radiation induced xerostomia.
Our lab is interested in how mesenchymal stromal cells can be utilized for treatment and prevention of radiation induced xerostomia. We have established mouse models of radiation induced xerostomia that we are using to study the molecular basis by which MSCs modulate the irradiated salivary gland. We also have NIH funding to support a first in human Phase I study utilizing MSCs in the treatment of radiation induced xerotomia.
Marrow-Derived Autologous Stromal Cells for the Restoration of Salivary Hypofunction (MARSH): Study protocol for a phase 1 dose-escalation trial of patients with xerostomia after radiation therapy for head and neck cancer: MARSH: Marrow-Derived Autologous Stromal Cells for the Restoration of Salivary Hypofunction.
Blitzer GC, Rogus-Pulia NM, Mattison RJ, Varghese T, Ganz O, Chappell R, Galipeau J, McDowell KA, Meyers RO, Glazer TA, Kimple RJ.
Cytotherapy. 2022 May;24(5):534-543. doi: 10.1016/j.jcyt.2021.11.003. Epub 2022 Feb 16.
Dichotomic Potency of IFNγ Licensed Allogeneic Mesenchymal Stromal Cells in Animal Models of Acute Radiation Syndrome and Graft Versus Host Disease.
Chinnadurai R, Bates PD, Kunugi KA, Nickel KP, DeWerd LA, Capitini CM, Galipeau J, Kimple RJ.
Front Immunol. 2021 Jul 26;12:708950. doi: 10.3389/fimmu.2021.708950. eCollection 2021.