Christian Capitini

Assistant Professor

Department: 

Pediatrics

Organ System/Disease Focus: 

Graft-versus-tumor effect for pediatric malignancies/GVHD

Aligned Research Focus: 

Allogeneic hematopoietic stem cell transplant

Research Description: 

Dr. Capitini's research focuses on using preclinical mouse models of allogeneic blood and marrow transplant (alloBMT) to cure pediatric leukemias and solid tumors with tumor-directed immunotherapeutic therapies such as dendritic cell vaccines, adoptive NK cell and T cell-based infusions. The goal of this research is to both improve presently used biological therapies in clinical alloBMT, such as donor lymphocyte infusion (DLI), as well as develop novel immune-based therapies that have potential to be translated into the clinic.

Selected References: 

  • Lockridge JL, Zhou Y, Becker YA, Ma S, Kenney SC, Hematti P, Capitini CM, Burlingham WJ, Gendron-Fitzpatrick A, Gumperz JE. Mice Engrafted with Human Fetal Thymic Tissue and Hematopoietic Stem Cells Develop Pathology Resembling Chronic Graft-versus-Host Disease. Biol Blood Marrow Transplant. 2013 Jun 24. PMID: 23806772.
  • Capitini CM, Nasholm NM, Duncan BB, Guimond M, Fry TJ. Graft-versus-host disease impairs vaccine responses through decreased CD4+ and CD8+ T cell proliferation and increased perforin-mediated CD8+ T cell apoptosis. J Immunol. 2013 Feb 1;190(3):1351-9. PMID: 23275602.
  • Capitini CM, Gottschalk S, Brenner M, Cooper LJ, Handgretinger R, Mackall CL. Highlights of the second international conference on "Immunotherapy in Pediatric Oncology". Pediatr Hematol Oncol. 2011 Sep;28(6):459-60. doi: 10.3109/08880018.2011.596615. Review. Erratum in: Pediatr Hematol Oncol. 2011 Oct;28(7):625. PMID: 21854215.
  • Capitini CM, Davis JP, Larabee SM, Herby S, Nasholm NM, Fry TJ. Extracorporeal photopheresis attenuates murine graft-versus-host disease via bone marrow-derived interleukin-10 and preserves responses to dendritic cell vaccination. Biol Blood Marrow Transplant. 2011 Jun;17(6):790-9. PMID: 21216299.

Group: 

Blood Research Program