Christian Capitini

Assistant Professor

Department: 

Pediatrics

Organ System/Disease Focus: 

Graft-versus-tumor effect for pediatric malignancies/GVHD

Aligned Research Focus: 

Allogeneic hematopoietic stem cell transplant

Research Description: 

Dr. Capitini focuses his research on using allogeneic hematopoietic stem cell transplant (alloHSCT) to cure pediatric cancers. The goal of this research is two-fold: to improve graft-vs.-tumor effects using immunotherapies that have potential to be translated into the clinic, and to reduce or eliminate graft-versus-host-disease (GVHD) through modulation of antigen presenting cells. Ongoing laboratory work is combining NK cells expanded with costimulatory molecules and gamma (c) cytokines with antibodies to stimulate NK cell proliferation and activation against several pediatric tumors in the alloHSCT setting. He is also developing MRI techniques to monitor NK cells in vivo. Clinically, Dr. Capitini is a site investigator for clinical trials studying chimeric antigen receptor (CAR)-modified T cells for relapsed leukemia.

Selected References: 

  • Elsaid M, Capitini CM, Diamond CA, Porte M, DeSantes KB: Successful matched unrelated donor stem cell transplant in Hemoglobin Bart’s disease. Bone Marrow Transplant. 2016 June 13, [ePub ahead of print] PMID: 27295273 PMCID: in process
  • Li Y*, Bouchlaka MN*, Wolff J, Grindle KM, Lu L, Qian S, Zhong X, Pflum N, Jobin P, Kahl BS, Eickhoff JC, Wuerzberger-Davis SM, Miyamoto S, Thomas CJ, Yang DT#, Capitini CM#, Rui L#: FBXO10 Deficiency and BTK Activation Upregulate BCL2 Expression in Mantle Cell Lymphoma. Oncogene 2016 May 9. [epub ahead of print] PMID: 27157620. PMCID: in process * = co-first authors, # = co-senior authors.
  • Bouchlaka MN, Ludwig KD, Gordon JW, Kutz MP, Bednarz B, Fain SB, Capitini CM: 19F-MRI for monitoring human NK cells in vivo. Oncoimmunology 2016; 5(5):e1143996. PMCID: in process
  • McDowell KA, Hank JA, DeSantes KB, Capitini CM, Otto M, Sondel PM: NK Cell-based Immunotherapies in Pediatric Oncology. Journal of Pediatric Hematology/Oncology 2015, 37(2): 79-93. PMCID: PMC4429888
  • Capitini CM*, Nasholm NM*, Chien CD, Larabee SM, Qin H, Song YK, Klover PJ, Hennighausen L, Khan J, Fry TJ: Absence of STAT1 in donor-derived plasmacytoid dendritic cells results in increased STAT3 and attenuates murine GVHD. Blood 2014 Sep 18;124(12):1976-86. * = Co-first authors. PMCID: PMC4168352.

Group: 

Blood Research Program