William L. Murphy

Bill Murphy
Professor, Biomedical Engineering, Orthopedics & Rehabilitation; Co-director, Stem Cell & Regenerative Medicine Center

Department: 

Biomedical Engineering / Orthopedics & Rehabilitation

Organ System/Disease Focus: 

Orthopedic and cardiovascular

Aligned Research Focus: 

Tissue engineering, controlled stem cell culture

Research Description: 

In the Bioinspired Materials Laboratory, we are interested in developing "smart" biomaterials that mimic the complex signaling environments of natural tissue development. We place particular emphasis on temporal and spatial control over growth factor activity, gene transfer, and mechanical stimulation.

The materials developed in our lab are then used to understand and control stem cell differentiation, ultimately geared towards directed regeneration of a variety of human tissues. Our group is highly interdisciplinary, with research areas ranging from novel materials design approaches to basic stem cell biology.

Selected References: 

  • K.E. Healy, T.C. McDevitt, W.L. Murphy, R.M. Nerem. Engineering the emergence of stem cell therapeutics. Science Translational Medicine, 2013;5:207.
  • S.Y. Choi, X. Yu, L. Jongpaiboonkit, S.J. Hollister, W.L. Murphy. Inorganic coatings for optimized non-viral transfection of stem cells. Scientific Reports, 2013; 3: 1567.
  • W.L. Murphy, T.C. McDevitt, A.J. Engler. Materials as stem cell regulators. Nature Materials, 2014; 13: 547-557.
  • E.H. Nguyen, M. Zanottelli, W.L. Murphy. Differential effects of cell adhesion, modulus and VEGFR-2 inhibition on capillary network formation in synthetic hydrogel arrays. Biomaterials, 2014; 35: 2149-2161.
  • X. Yu, P.N. Dang, A.S. Khalil, E. Alsberg, W.L. Murphy Tunable dual growth factor delivery using multilayered microparticles with controllable degradation kinetics. Advanced Functional Materials, 2014; 24: 3082–3093.

Group: 

Stem Cell Bioengineering
Cardiovascular Regeneration
Musculoskeletal Regeneration