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Daniel Radecki, Research Associate, Comparative Biosciences (Samanta lab), “Novel Regulation of Neural Stem Cell Remyelination by GPNMB”
February 5 @ 12:00 pm - 1:00 pm
Topic: Novel Regulation of Neural Stem Cell Remyelination by GPNMB
Abstract: The central nervous system (CNS) contains two main stem cell niches that generate cells during development, in the adult CNS, and upon disease or injury insult. One set of these adult neural stem cells (NSCs) niches is located in the subventricular zone (SVZ), also referred to as the subependymal zone (SEZ). NSCs in the SEZ have the ability to self-renew and divide to generate the three major cell types of the CNS; neurons, astrocytes, and oligodendrocytes. The myelin producing oligodendrocytes are critical for axonal health and maintenance, and degenerate in demyelinating diseases, such as the autoimmune mediated disease Multiple Sclerosis (MS). Promoting regeneration of oligodendrocytes and subsequent remyelination is a goal of MS therapeutics, as increased remyelination can improve clinical outcomes. Using a mouse model of demyelination followed by RNA-seq analysis of NSCs, our lab has identified a potential regulator of NSCs; glycoprotein non-metastatic melanoma b (GPNMB). The function of GPNMB in the CNS is unknown, although qualitative analysis of MS lesions indicates an increase in GPNMB levels in patients. Our lab is working to define the pathway(s) involved in GPNMB regulation, as well as its effects on NSC differentiation, survival, and proliferation in vitro and in vivo. Because its role in CNS development is also unknown, we are characterizing the expression pattern of GPNMB during development, in the healthy and demyelinated adult CNS. These ongoing studies will define the function and regulation of GPNMB in adult neural stem cells of the healthy and demyelinated CNS, and the potential for GPNMB as a therapeutic in demyelinating diseases.