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Li-Fang Chu, PhD, Associate Scientist, Regenerative Biology, James Thomson Lab, Morgridge Institute for Research, “Pluripotency, Embryonic Stem Cells, and the Developmental Clock”
April 14, 2020 @ 12:00 pm - 1:00 pm
The UW Stem Cell & Regenerative Medicine Center will continue to offer its weekly seminar, but we will transition to ONLINE only. We will be offering this live (synchronously), so you can participate in the Q & A session in real time.
To connect and join our live Tuesday Stem Cell Seminar Series (now online), please click on this public link: https://us.bbcollab.com/guest/ecfe2a1900ab4a6ca9bd6b20e4b7bb07
We do encourage you all to review the instructions, linked below, in order to orient yourselves to this environment. You are also welcome to jump into the room and test your ability to connect, including turning on your audio and video. Our center’s Administrator, Hollie, will be in the room starting at 10:30 AM CT and can offer assistance as time allows.
Guest Access Instructional Overview: https://go.wisc.edu/ftti09
If you have any questions, please contact Hollie: firstname.lastname@example.org
**STUDENTS: If you are a current student, an announcement has been posted to your Canvas course with instructions on how to access the course. IF you have issues getting into Canvas, please use guest link and let Hollie know via email.
Pluripotency, Embryonic Stem Cells, and the Developmental Clock
A fascinating feature of embryonic development is the reproducibility of temporal developmental programs (e.g., somite and limb formation) among individuals of the same species. Between different species, however, developmental timing varies drastically; human gestation is roughly 40 weeks, while mice require only 3 weeks. Remarkably, the differentiation rate of human and mouse pluripotent stem cells (PSCs), including embryonic stem cells and induced pluripotent stem cells, recapitulates species-specific timing (mouse PSCs differentiate much faster than human PSCs). This suggests that without normal developmental cues from an intact embryo, a largely unknown intrinsic timing mechanism exists in PSCs in vitro. My presentation will focus on three stories:
1) Investigating how embryonic stem cells and the pluripotent state arise in vitro.
2) Single-cell RNA-seq analysis on temporal cell state transitions; and 3) Modeling a developmental clock in vitro. My long-term research interest is to understand the developmental timing mechanisms that control cell fate during differentiation and embryonic development.