Patrick C.H. Hsieh, MD, PHD, Visiting Professor, Institute of Biomedical Sciences, Academia Sinica, “The gut microbiota modulates heart repair after infarction”
October 23 @ 12:00 pm - 1:00 pm
Topic: The gut microbiota modulates heart repair after infarction
Abstract: The impact of gut microbiota on regulation of host physiology has recently garnered considerable attention, particularly in key areas such as the immune system and metabolism. These areas are also crucial for the pathophysiology of and repair after myocardial infarction (MI). However, the role of the gut microbiota in the context of MI remains to be fully elucidated.
To investigate the effects of gut microbiota on cardiac repair after myocardial infarction (MI), mice were treated with antibiotics 7 days prior to MI to deplete mouse gut microbiota. Antibiotic treated mice (ABX mice) displayed drastic, dose-dependent mortality after MI. We observed an association between the gut microbiota depletion and significant reductions in proportion of myeloid cells and short-chai fatty acid (SCFA), more specifically acetate, butyrate and propionate. Infiltration of CX3CR1+ monocytes to the peri-infarct zone after MI was also reduced, suggesting impairment of repair after MI. Accordingly, the physiological status and survival of mice were significantly improved following fecal reconstitution, transplantation of monocytes or dietary SCFA supplementation. MI was associated with reorganization of the gut microbial community, such as a reduction in Lactobacillus. Supplementing ABX mice with a Lactobacillus probiotic prior to MI restored myeloid cell proportions, yielded cardioprotective effects and shifted the balance of SCFAs towards propionate.
We conclude that the gut microbiota-derived SCFAs play an important role in maintaining host mmune composition and repair capacity after MI. This suggests that manipulation of these elements may provide opportunities to modulate pathological outcome after MI, and indeed human health and disease as a whole.