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Dr. Yunlong Tao, Research Associate – Dr. Zhang’s Stem Cell Research Laboratory, “Cell Therapy for Parkinson’s Disease – Preclinical Studies in Rodents and Non-human Primates”
January 26 @ 12:00 pm - 1:00 pm
The UW Stem Cell & Regenerative Medicine Center will continue to offer its weekly seminar online in a live (synchronously) format, so that you, as all can continue to participate in the Q & A session in real time.
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Cell Therapy for Parkinson’s Disease – Preclinical Studies in Rodents and Non-human Primates
Dr. Yunlong Tao
Dr. Zhang’s Stem Cell Research Laboratory
Degeneration of dopamine (DA) neurons in the midbrain underlies the pathogenesis of Parkinson’s disease (PD). Supplement of DA via L-Dopa alleviates motor symptoms but does not prevent the progressive loss of DA neurons. A large body of experimental studies, including those in nonhuman primates, demonstrates that transplantation of fetal mesencephalic tissues improves motor symptoms in animals, which culminated in open-label and double-blinded clinical trials of fetal tissue transplantation for PD. Unfortunately, the outcomes are mixed, primarily due to the undefined and unstandardized donor tissues. Generation of induced pluripotent stem cells (iPSCs) enables standardized and unlimited cell source for PD. In this talk, I will present our pre-clinical studies using stem cell derived DA neurons in rodent and non-human primate PD models to evaluate the cell therapy for PD.