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Brady Lundin, Ashton Lab, presents “A Scalable Human RosetteArrayTM Assay for Quantitative Prediction of Environmental and Genetic Neural Tube Defect Risk”
September 19 @ 12:00 pm - 1:00 pm
Our Seminar Lab Series will be offered in hybrid format this Fall
- The in-person seminar is being held at the Wisconsin Institute for Discovery, DeLuca Forum.
- There will be sandwiches provided again this term!! Come join us!
- To join online, please click the zoom link below:
- *if you are asked for a passcode: 936743
“A Scalable Human RosetteArrayTM Assay for Quantitative Prediction of Environmental and Genetic Neural Tube Defect Risk”
“Neural tube defects (NTDs) remain the second most common congenital malformation. Given their complicated multifactorial etiology and species differences in neural tube closure, current in vitro models (mainly gene altered rodents) have struggled to investigate clinical NTD pathophysiology and interventions due to their limited scale and non-human background. Human pluripotent stem cell derived RosetteArrays are a standardized and quantifiable model of neural tube closure and enable modeling of discrete central nervous system regional identities, i.e., forebrain vs spinal cord. This talk will demonstrate preliminary results of the RosetteArray’s ability to model and quantify NTD susceptibility based on environmental/pharmacological risk factors and individual genetic variants in a human etiological background.”