Courses to Satisfy Stem Cell Science Certificate Academic Requirement

Required Seminar Course


CRB 675 Stem Cell Seminar

1

Capacity 30 Fall, Spring
The structure builds off a weekly seminar series given by campus stem cell scientists and visiting speakers on topics across the spectrum of stem cell and regenerative medicine research. Students are encouraged to participate in the discussion and are provided a study question following each seminar.

Options for Ethics and Policy Courses to satisfy Ethics requirement


HstSci 133 Biology and Society, 1950–today

3

Capacity: 240 Spring
 This course explores events in the history of biology from the mid-twentieth century to today, and examines how developments in these scientific fields have shaped and are shaped by society

Law 905 Bioethics and the Law

2-4

Fall
Introduction to the legal, ethical and public policy dimensions of modern medicine and biomedical research. Informed consent, human experimentation, death and dying, organ transplantation, allocation of scarce resources. May cover reproductive and genetic issues in some years.

Law 906 Law, Science and Biotechnology

2-4

Fall
This course will examine how law shapes the development and introduction of new biomedical technologies, and how complex social forces shape the law with respect to new technologies. We will study several new and emerging technologies including stem cells, gene therapy, genetic testing and new reproductive technologies. Several course sessions will focus on the regulation of human subjects’ research, and the evolution of this body of law in response to the changing nature of biomedical research. You do not need a science background to understand the material or to excel in the course.

L SC Com 251 Science, Media, and Society

3

Spring
Introduction to communication at the intersection of science, politics and society. Overview of the theoretical foundations of science communication and their relevance for societal debates about science and emerging technologies.

Med Hist 565 Ethic of Modern Biotechnology

3-4

Fall, Spring
Covers policy and ethical issues arising from applying modern biotechnology to microorganisms, plants, and animals. 1 week on using human stem cells to create human/animal chimeras. Also typically discusses intellectual property.

Med Hist (MHB) 610 / 615 Regenerative Medicine Ethics and Society

1-3

Capacity 20 Spring
This course is designed to introduce upper-level undergraduate students to ethical, policy and social issues related to novel areas of medical science, with a focus on regenerative medicine. We will focus on stem cell research and related areas of regenerative medicine, and nanobiomedicine. The course is interdisciplinary: we will use material from history, social science, ethics, humanities, communications/media as well as public policy.

Phil 341 Contemporary Moral Issues

3-4

Capacity 42 Spring
A philosophical study of some major moral issue in contemporary society, such as those concerning abortion, euthanasia, punishment, property, politics, sex, nuclear disarmament, and world hunger.

Phil 342 Contemporary Moral Issues

3-4

Capacity 42 Fall / Spring
This course will give us the opportunity to think deeply about four controversial and difficult moral issues: 1) surrogate motherhood, 2) abortion, 3) inequalities of income, wealth, and health, and 4) health care. In addition, to provide some perspective and depth in our consideration of the particular issues, we shall spend some time with ethical theory.

STS 201 Where Science Meets Society

3

Capacity 25 Fall
Explores science and technology as important and central institutions in modern societies. This course explores the relationship between science, technology, and society. It is premised on the idea that science and technology affect our social, cultural, economic, and political lives, and equally scientific research and technology development are shaped by their social, cultural, economic, and political context. We will approach the ways in which science and technology “meet society” through a series of case studies that range from refrigerators to climate change.

Options to Satisfy Stem Cell Course Requirements


An Sci 375 Lab Techniques in Gamete and Embryo Biology

3

Capacity 16 Summer
A lecture and laboratory course in gamete and embryo biology, in vitro fertilization and embryo development and culture. Includes discussion of stem cell pluriopotency and function.

An Sci 434 Reproductive Physiology

3

Capacity 80 Fall
Principles of reproductive physiology, improvement of fertility, and artificial insemination.

Biochem 550 Topics in Medical Biochemistry

2

Capacity 48 Spring
Biochemical and molecular analysis of selected human diseases. Topics will include lipid metabolism and atherosclerosis, cell cycle regulation and oncogene function in cancer, and human immunodeficiency virus (HIV) structure, life cycle, and mechanism of acquired immunodeficiency disease syndrome (AIDS).

Biochem 620 Eukaryotic Gene Regulation

3

Capacity 90 Spring
This course focuses on the basic molecular mechanisms that regulate DNA, RNA, and protein metabolism in eukaryotic organisms. This course is intended for advanced undergraduates and first year graduate students with a firm knowledge of basic biochemistry.

Biochem 630 Cellular Signal Transduction Mechanisms

3

Capacity 91 Fall
Comprehensive coverage of human hormones, growth factors and other mediators; emphasis on hormone action and biosynthesis, cell biology of hormone-producing cells.

Biocore 303 Cellular Biology

3

Capacity 112 Spring
Cellular and molecular basis of life. The main themes are the structure and function of cells and organelles, the flow of energy in cells, and the storage, expression, and regulation of genetic information

Biocore 304 Cellular Biology Lab

2

Capacity 112 Spring
Writing-intensive course in which students undertake projects in areas such as enzyme catalysis, subcellular fractionation, motility, growth of bacteriophage, genetic mapping, genetic analysis of a biochemical pathway, and transformation of bacterial cells with DNA.

Biomol Chem 503 Human Biochemistry

3

Capacity 184 Spring
Lectures and conferences on basic principles of biological chemistry with emphasis on its application to the medical sciences.

BME 320 Introductory Transport Phenomena

4

Capacity 65 Fall, Spring
Mass, momentum, and energy transport; calculation of transport coefficients; solution to problems in viscous flow, heat conduction, and diffusion; dimensional analysis; mass, momentum, and heat transfer coefficients; over-all balances; elementary applications.

BME 430 Biological Interactions with Materials (Biomaterials)

3

Capacity 115 Spring
This course addresses the range of materials currently being utilized for various biomedical applications, the biological systems governing biomaterial applications, analytical techniques pertinent to biomaterial evaluation, and selected major medical applications in which biomaterials play an important role.

BME 545 Extracellular Matrix: Controlling Structure and Function

3

Capacity 25 Spring
Overview of the structure, function and biophysical properties of extracellular matrix (ECM) proteins, followed by discussion of how control or manipulation of ECM protein expression and distribution impacts on cell and tissue function, concluding with impacts of engineering ECM for regenerative medicine.

BME 510 Introduction to Tissue Engineering

3

Capacity 38 Fall
Overview of tissue engineering, including discussion of cell sources, cell-material interactions, tailoring biomaterials, methods of culture and characterization of engineering tissues, ethical issues, concluding with case studies of specific types of tissue engineering. Optional laboratory exercises offered throughout semester.

BME 520 Stem Cell Bioengineering

3

Capacity 40 Fall
Covers engineering approaches that are used to understand and manipulate stem cells. Concepts covered include: introduction to stem cell biology, quantitative modeling of stem cell signaling, methods to engineer the stem cell microenvironment, and the role of stem cells in tissue development and regeneration.

BME 603 Topics in Engineering: Biomechanics of Movement

3

Capacity 24 Fall
Various aspects of living systems of interest to the mechanical engineer, such as the mechanics of hearing and vision, cardiac and central nervous systems, artificial organs, blood flow behavior, and energy-transfer processes.

CRB 615 Regenerative Medicine Ethics AND Society

3

Capacity 80 Fall
Study of regenerative medicine and stem cell research within social, ethical and political contexts.

CRB 640 Fundamentals of Stem Cell and Regenerative Biology

3

Capacity 80 Fall
The course will provide a foundation to understand fundamental biological, mechanistic, and experimental concepts in the field of stem cell and regenerative biology. The course is designed for graduate students and advanced undergraduates with a significant background in one or more of the following fields: biochemistry, molecular biology and cell biology.

CRB 650

 

Molecular and Cellular Organogenesis

3

Capacity 30 Spring
This course will cover the most current knowledge of the basic principles of organogenesis including the molecular and cellular pathways leading to normal organ development. Tissue/organ specification, differentiation, and developmental processes, focusing on molecular signals and associated signal transduction pathways and transcriptional regulation will be covered in depth. Depending on the organ, current understanding of the role of stem cells and the molecular basis for congenital disease will be included.

CRB 675 Mammalian Embryogenesis

3

Capacity 15 Fall
This course will provide graduate and advanced undergraduate students with a thorough grounding in mammalian embryology. Emphasis is on the anatomy of the mouse conceptus, the experimental approaches used to investigate cell fate, cell potency, determination, and differentiation, how these approaches have formed the basis for isolating a variety of stem cell types, and the role of spatial coordinates in embryonic and extraembryonic design and juxtaposition.

Genetics 520 Neurogenetics

2

Capacity ? Fall, Spring
Genetic basis of neural development and function, the genetic basis of neurodevelopmental disorders, and the genetic approaches to studying the development, function, and diseases of the nervous system.

Genetics 564 Introduction to Genomics and Proteomic Analysis

3

Capacity 25 Spring
The basic principles of genomics, proteomics and bioinformatics will be taught through readings of the scientific literature, class presentations, group projects and computer lab web-based experiences. Emphasis will be placed upon student participation in the learning process. Some topics covered will be: genomic sequencing, motif discovery, DNA microarray, high-throughput genetics, chemical genetics, mass spectrometry techniques and protein networks.

Genetics 627 Developmental Genetics

3

Capacity 88 Spring every other year
This is a new upper level Genetics course focusing on molecular mechanisms of animal embryonic development, with particular emphasis on genetic analytical tools. Using primary research literature, we will address topics including maternal and epigenetic inheritance, the egg-to-embryo transition, pattern formation, coordination of cellular and patterning mechanisms, organogenesis, and animal models of human developmental syndromes. Class time will be divided into lectures, in-class group discussion and activities and student’s research article presentations.

Hist Sci 203 Science in the 20th Century:  A Historical Overview

3

Capacity 88 Fall
Major themes in the physical, biological and environmental sciences from 1890 to the present. Attention to conceptual development, interaction of science and society, philosophical issues, and personalities in science.

L Sc Com 251 Science, Media, and Society

3

Capacity 25 Spring
Introduction to communication at the intersection of science, politics and society. Overview of the theoretical foundations of science communication and their relevance for societal debates about science and emerging technologies.

Med Hist 333 History of Modern Biology

3

Capacity 30 Spring (2013)
Survey of major developments in biology and related sciences ca. 1700-1950. Topics include morphology and embryology; evolutionary theory, ecology, and genetics; physiology and recent experimental biology.

Med Hist 526 Medical Technology and the Body

3

Capacity 28 Fall
Ethical and cultural dimensions of chemical, surgical and bioengineering modifications and enhancements to the human body.

Med Phys 471 Multi-modality Molecular Imaging in Living Subjects

2

Capacity 15 Spring (every other year)
Molecular imaging is an interdisciplinary field that has witnessed tremendous progress over the last decade. Molecular imaging techniques generally include molecular magnetic resonance imaging (mMRI), magnetic resonance spectroscopy (MRS), optical bioluminescence, optical fluorescence, targeted ultrasound, single-photon emission computed tomography (SPECT), positron emission tomography (PET), and a few other techniques that are under active development.

This 2 credit class will give a brief overview of the various aspects in molecular imaging. Some of the topics include: role of molecular imaging in stem cell research, molecular imaging with nanoparticles, molecular imaging in drug development, optical imaging and its clinical applications, reporter gene imaging, imaging of apoptosis, PET imaging of cancer, among others.


Neurosci 610 Cellular and Molecular Neuroscience

4

Capacity 70 Fall
Study of original papers leading to an understanding of the molecular basis of electrical activity in neurons. Topics include voltage-sensitive currents, molecular biology of neuronal receptors, synaptic transmission and sensory transduction. Lectures supplemented with experimental demonstrations and discussion sessions.

Neurosci 625 Brain Cell Culture and Imaging: A Laboratory Course

4

Capacity 12 Fall
Hands-on laboratory training in neuronal cell culture, live and fixed neuron labeling and microscopy techniques to visualize neurons in culture, as well as image analysis methods.

Neurosci 670 Stem Cells and the Central Nervous System

3

Capacity 20 Fall
The goal of this course is to introduce the concept, updated research, and therapeutic potentials of neural stem cells to graduate students and advanced senior undergraduate students. The course will cover topics ranging from neural stem cells in development to adult, and during aging, as well as NSCs derived from patient-specific pluripotent stem cells and disease modeling. Each week there will be one faculty lecture, and one journal club presented by students. Students will be given a group project based on creating an experimental approach to address a novel scientific question as a final project in the course.

Neurosci 765 Developmental Neuroscience

3

Capacity 20 Spring
Analysis of neural development with emphasis on experimental approaches. Combination of lectures and discussions of primary literature. Topics include neural induction, patterning, mechanisms of axon guidance, neural crest cell migration and differentiation, cortical development, and synapse formation and elimination.

Path 803 Pathogenesis of Major Human Diseases

3

Capacity 30 Fall
This course will focus on diseases that are major causes of global death and disability. Throughout the course, we will combine expert clinicians, basic scientists, and literature review on specific topics. For each major disease there will be three seminars. The first seminar will introduce the pathogenesis and current clinical treatments of major human diseases. The next seminar will focus on experimental models to study the disease pathogenesis. The last session will consist of small groups reviewing current research papers addressing disease pathogenesis and discussing the leading disease model. The course is designed for graduate students, MD or MD/PHD students and advanced undergraduates interested in pursuing a career in bench-to-bedside translational, basic and clinical research. The course will provide an opportunity to learn about research currently being conducted on specific human diseases. The major human diseases covered will include Cancer, Tuberculosis, HIV/AIDS, Malaria, Stroke, Alzheimer’s Disease, Diabetes, Multiple Sclerosis, and Asthma.

Phil / Med History 558 Ethical Issues in Healthcare

3

Capacity unknown Spring
Ethical issues apparently created by new biomedical technologies, such as genetic screening, prenatal diagnosis, prolongation of life, treatment of severe birth defects, in vitro fertilization, behavior modification, psychosurgery, and transplantation. Postdoc eligibility: Postdocs may apply to be guest auditors. As guest auditors they are restricted to listening and cannot participate in the discussion.

Psych 454 Behavioral Neuroscience

3

Capacity unknown Spring or Fall
Biological basis of human and animal behaviors, including perception, action, cognition, social interaction and disease. Weekly themes from “Cracking the Neural Code” to “Love and War”. Students learn, develop and use neural mechanisms to explain and (attempt to) predict what they and others think and do in all facets of life.”

Zool 470 Introduction to Animal Development

3

Capacity 171 Spring
This course introduces students to the major features and mechanisms of early embryonic development in animals, including (1) the major stages of early development, (2) how form arises in the embryo (morphogenesis), (3) how differences arise between cells in the embryo, and (4) how specific genes control these processes.

Zool 523 Neurobiology I

3

Capacity 200 Fall
Basic mechanisms in cellular neurophysiology: electrophysiology and chemistry of nerve signals, mechanisms in integration, simple nervous pathways and their behavioral correlates.

Zool 524 Neurobiology II

3

Capacity 150 Spring
An introduction to studies of the human nervous system covering neuroanatomy of the brain, neuronal coding, sensory and motor systems, biological rhythms, arousal, attention, physiological regulation, reward, aversion, learning and memory.

Zool 555 Laboratory in Developmental Biology

3

Capacity 10 Fall
Developmental anatomy and laboratory manipulations of representative animal embryos used extensively for analysis of developmental phenomena (sea urchins, amphibia, annelids, mollusks, ascidians, insects, chicks, fish, mice).

Zool 570 Cell Biology

3

Capacity 200 Fall
Comprehensive course on modern aspects of cell biology.

Zool 625 Development of the Nervous System

2

Capacity 50 Every other Spring
Survey of the principles guiding neuronal development. Course will cover descriptive and experimental analyses of developmental mechanisms underlying the formation of both vertebrate and invertebrate nervous systems.

Zool 960 Repair and Regeneration

1

Capacity 20 Starting in Spring 2018
For graduate students and advanced undergraduates. The course is concerned with the biological underpinnings of cell and tissue repair and regeneration.  Part lecture, part student presentations. Grades will be based on class participation, a class presentation, and a 2-5 page research paper.

Prerequisites:  Cell Biology, Developmental Biology, Biochemistry. Prerequisites can be waived with consent of the instructors.