The Kiessling Laboratory
Faculty > Laura L. Kiessling
Laura L. Kiessling
Hilldale Professor of Chemistry
Laurens Anderson Professor of Biochemistry
kiessling@chem.wisc.edu
Kiessling Laboratory Home Page
Organ System/Disease Focus
None
Aligned Research Focus
Basic stem cell biology
Research Description
We use chemical biology to understand and manipulate stem cells. We have developed high throughput strategies to synthesize and screen novel surfaces and biomaterials to identify substrates that can be used to promote stem cell proliferation and differentiation.
Selected References
R. Derda, S. Musah, B. P. Orner, J. R. Klim, L. Li, and L. L. Kiessling (2010). High-throughput Discovery of Synthetic Surfaces that Support Proliferation of Pluripotent Cells. J. Am. Chem. Soc. 132, 1289-1295, DOI: 10.1021/ja906089g.
L. Li, B. P. Orner, T. Huang, A. P. Hinck and L. L. Kiessling (2010). Peptide Ligands That Use a Novel Binding Site to Target Both TGF-β Receptors, Mol. Biosyst 6, 2392-2402. DOI: 10.1039/C0MB00115E; PMID: 20890540
J. R. Klim, L. Li, and L. L. Kiessling (2010). A Defined Glycosaminoglycan-Binding Substratum for Human Pluripotent Stem Cells, Nat Methods 7, 989-994. PMID: 21076418
L. Li, J. R. Klim, R. Derda, A. H. Courtney, and L. L. Kiessling (2011). Spatial Control of Cell Fate Using Synthetic Surfaces to Potentiate TGF-b Signaling, Proc. Natl. Acad. Sci. 108, 11745-11750. PMID: 21719709.
J. R. Klim, A. J. Fowler , A. H. Courtney, P. J. Wrighton, R. T. C. Sheridan, M. L. Wong, and L. L. Kiessling (2012). Small Molecule-Modified Surfaces Engage Cells Through the αvβ3 Integrin, ACS Chem Biol. ASAP, DOI: 10.1021/cb2004725.