The Sheibani Laboratory
Faculty > Nader Sheibani
Nader Sheibani
Professor of Ophthalmology and Visual Sciences
nsheibanikar@wisc.edu
Organ System/Disease Focus
Retina/ Diabetic Retinopathy and Age-Related Macular Degeneration
Aligned Research Focus
Vascular Cell Biology
Research Description
My major research interest is how angiogenesis is regulated with a focus on the role of endogenous inhibitors of angiogenesis. We have recently become interested in potential contribution of endothelial progenitor cells in angiogenesis and what determines their appropriate differentiation to vascular cells during this process. We are also interested in the function of perivascular mesenchymal stems cells in angiogenesis and their dysfunction during diabetes.
Selected References
DiMaio TA, Wang S, Huang Q, Scheef EA, Sorenson CM and Sheibani N. (2008) Attenuation of retinal vascular development and neovascularization in PECAM-1 deficient mice. Developmental Biol. 315:72-88. PMCID: PMC2275901
Sehgal R, Sheibani N, Rhodes SJ, Belecky Adams TL. (2009) BMP7 and SHH regulate Pax2 in retinal astrocytes by relieving TLX repression. Dev Biology 332:429-43.
Wang S, Sorenson CM, Sheibani N. Lack of Thrombospondin 1 and Exacerbation of Choroidal Neovascularization. Arch Ophthalmol. 2012 Jan 9. [Epub ahead of print] PMID: 22232368
Dutta D, Ray S, Home P, Saha B, Wang S, Sheibani N, Tawfik O, Cheng N, Paul S. (2010) Regulation of angiogenesis by histone chaperone HIRA-mediated incorporation of lysine 56-Acetylated histone H3.3 at chromatin domains of endothelial genes. J Biol Chem. 285:41567-41577. PMCID: PMC3009884
Tu Z, Li Y, Smith DS, Sheibani N, Huang S, Kern T, Lin F. (2011) Retinal Pericytes inhibit activated T cell proliferation. Invest Ophthalmol Vis Sci. 52:9005-10 PMID: 22003106 [PubMed - in process]